DegronMD - A6NEE1(PLEKHD1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R315C	TCGA-AA-3984	COAD	TCGA	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.2778
p.R315C	DO9002	COAD	ICGC	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.2778
p.R315C	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.2778
p.L304P	TCGA-B0-5709	KIRC	TCGA	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.1944
p.L304P	DO16607	KIRC	ICGC	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.1944
p.R315H	DO224802	BRCA	ICGC	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.2778
p.R315H	DO8658	COAD	ICGC	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.2778
p.R315H	DO50398	ESAD	ICGC	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.2778
p.R315H	SIDM01181	Hepatocellular Carcinoma	GDSC	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.2778
p.R323C	DO230311	COCA	ICGC	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.0556
p.R323C	DO38376	STAD	ICGC	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.0556
p.E313K	DO222402	MELA	ICGC	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation altering degron motif	0.591
p.R308W	SIDM00216	Colorectal Carcinoma	GDSC	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.3056
p.R308W	SNU-175	large intestine	COSMIC	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.3056
p.R317W	SIDM01113	Other Sarcomas	GDSC	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.2222
p.R317W	SIDM00999	Bladder Carcinoma	GDSC	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.2222
p.R317W	ACH-000939	Sarcoma	CCLE	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.2222
p.R317W	ACH-000973	Bladder Cancer	CCLE	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.2222
p.R317W	639-V	urinary tract	COSMIC	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.2222
p.R317W	SK-UT-1	soft tissue	COSMIC	MKENE	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHD1

UniProt ID: A6NEE1

Entrez ID: 400224

Protein name: Pleckstrin homology domain-containing family D member 1 (PH domain-containing family D member 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHD1 in