DegronMD

Uniprot ID: A6NEE1

Source protein: Pleckstrin homology domain-containing family D member 1

Source gene: PLEKHD1

Class: DEG_APCC_KENBOX_2

Location: 309:313

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7627

ASA_SCORE: 108.38

COIL: 0.0356

CONS_SCORE: 0.5845

DSS_SCORE: 0.5085

HELIX: 0.9678

FCONS_SCORE: 1.1822

RIG_SCORE: 0.6933

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R315C	TCGA-AA-3984	COAD	TCGA	MKENE	DEG_APCC_KENBOX_2	0.2778
p.R315C	DO9002	COAD	ICGC	MKENE	DEG_APCC_KENBOX_2	0.2778
p.R315C	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	MKENE	DEG_APCC_KENBOX_2	0.2778
p.L304P	TCGA-B0-5709	KIRC	TCGA	MKENE	DEG_APCC_KENBOX_2	0.1944
p.L304P	DO16607	KIRC	ICGC	MKENE	DEG_APCC_KENBOX_2	0.1944
p.R315H	DO224802	BRCA	ICGC	MKENE	DEG_APCC_KENBOX_2	0.2778
p.R315H	DO8658	COAD	ICGC	MKENE	DEG_APCC_KENBOX_2	0.2778
p.R315H	DO50398	ESAD	ICGC	MKENE	DEG_APCC_KENBOX_2	0.2778
p.R315H	SIDM01181	Hepatocellular Carcinoma	GDSC	MKENE	DEG_APCC_KENBOX_2	0.2778
p.R323C	DO230311	COCA	ICGC	MKENE	DEG_APCC_KENBOX_2	0.0556
p.R323C	DO38376	STAD	ICGC	MKENE	DEG_APCC_KENBOX_2	0.0556
p.E313K	DO222402	MELA	ICGC	MKENE	DEG_APCC_KENBOX_2	0.591
p.R308W	SIDM00216	Colorectal Carcinoma	GDSC	MKENE	DEG_APCC_KENBOX_2	0.3056
p.R308W	SNU-175	large_intestine	COSMIC	MKENE	DEG_APCC_KENBOX_2	0.3056
p.R317W	SIDM01113	Other Sarcomas	GDSC	MKENE	DEG_APCC_KENBOX_2	0.2222
p.R317W	SIDM00999	Bladder Carcinoma	GDSC	MKENE	DEG_APCC_KENBOX_2	0.2222
p.R317W	ACH-000939	Sarcoma	CCLE	MKENE	DEG_APCC_KENBOX_2	0.2222
p.R317W	ACH-000973	Bladder Cancer	CCLE	MKENE	DEG_APCC_KENBOX_2	0.2222
p.R317W	639-V	urinary_tract	COSMIC	MKENE	DEG_APCC_KENBOX_2	0.2222
p.R317W	SK-UT-1	soft_tissue	COSMIC	MKENE	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NEE1	Pleckstrin homology domain-containing family D member 1	DEG_APCC_KENBOX_2	309:313	MKENE	APC,CDC20,FZR1	0.7627	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons