DegronMD - A6NEH6(TMEM247)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A90T	TCGA-A6-2684	COAD	TCGA	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.2778
p.A90T	DO10236	COAD	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.2778
p.G86R	TCGA-DX-A8BP	SARC	TCGA	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.1667
p.G86R	DO225206	BRCA	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.1667
p.G86R	DO228163	PBCA	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.1667
p.G86R	DO220056	SARC	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.1667
p.Q82K	DO228750	GACA	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0556
p.R100C	DO233089	GACA	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.3056
p.A83T	DO222557	MELA	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.M104I	DO222868	MELA	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.1944
p.M104I	SIDM00535	Chondrosarcoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.1944
p.M104I	ACH-001519	Bone Cancer	CCLE	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.1944
p.M104I	H-EMC-SS	bone	COSMIC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.1944
p.D85N	DO38404	STAD	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.1389
p.A83V	SIDM00075	Non-Cancerous	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.A83V	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.A83V	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.A83V	SIDM00057	Neuroblastoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.A83V	SIDM00552	Rhabdomyosarcoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.A83V	SIDM00492	Glioblastoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.A83V	SIDM01196	Hepatocellular Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.A83V	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.A83V	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.A83V	SIDM00024	Non-Cancerous	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.A83V	SIDM00365	Small Cell Lung Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.A83V	SIDM00549	B-Lymphoblastic Leukemia	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.A83V	SIDM00271	Gastric Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.A83V	SIDM00241	Breast Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.A83V	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.A83V	SIDM00591	Oral Cavity Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.0833
p.E91G	SIDM00845	Burkitt's Lymphoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.3056
p.E91G	SIDM00793	Burkitt's Lymphoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.3056
p.E91G	SIDM00863	Burkitt's Lymphoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.3056
p.E103K	SIDM00832	Colorectal Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.2222
p.E103K	ACH-000680	Colon/Colorectal Cancer	CCLE	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.2222
p.E103K	SW948	large intestine	COSMIC	LPPTPGTE	DEG_SCF_FBW7_2	92:99	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM247

UniProt ID: A6NEH6

Entrez ID: 388946

Protein name: Transmembrane protein 247

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM247 in