DegronMD

Uniprot ID: A6NEH6

Source protein: Transmembrane protein 247

Source gene: TMEM247

Class: DEG_SCF_FBW7_2

Location: 92:99

E3 ligase: FBXW7

DEGRON score: 0.8858

ASA_SCORE: 76.2

COIL: 0.9183

CONS_SCORE: 0.5319

DSS_SCORE: 0.7942

HELIX: 0.0393

FCONS_SCORE: 0.6937

RIG_SCORE: 0.5741

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A90T	TCGA-A6-2684	COAD	TCGA	LPPTPGTE	DEG_SCF_FBW7_2	0.2778
p.A90T	DO10236	COAD	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	0.2778
p.G86R	TCGA-DX-A8BP	SARC	TCGA	LPPTPGTE	DEG_SCF_FBW7_2	0.1667
p.G86R	DO225206	BRCA	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	0.1667
p.G86R	DO228163	PBCA	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	0.1667
p.G86R	DO220056	SARC	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	0.1667
p.Q82K	DO228750	GACA	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	0.0556
p.R100C	DO233089	GACA	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	0.3056
p.A83T	DO222557	MELA	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.M104I	DO222868	MELA	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	0.1944
p.M104I	SIDM00535	Chondrosarcoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.1944
p.M104I	ACH-001519	Bone Cancer	CCLE	LPPTPGTE	DEG_SCF_FBW7_2	0.1944
p.M104I	H-EMC-SS	bone	COSMIC	LPPTPGTE	DEG_SCF_FBW7_2	0.1944
p.D85N	DO38404	STAD	ICGC	LPPTPGTE	DEG_SCF_FBW7_2	0.1389
p.A83V	SIDM00075	Non-Cancerous	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.A83V	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.A83V	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.A83V	SIDM00057	Neuroblastoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.A83V	SIDM00552	Rhabdomyosarcoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.A83V	SIDM00492	Glioblastoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.A83V	SIDM01196	Hepatocellular Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.A83V	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.A83V	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.A83V	SIDM00024	Non-Cancerous	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.A83V	SIDM00365	Small Cell Lung Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.A83V	SIDM00549	B-Lymphoblastic Leukemia	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.A83V	SIDM00271	Gastric Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.A83V	SIDM00241	Breast Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.A83V	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.A83V	SIDM00591	Oral Cavity Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.0833
p.E91G	SIDM00845	Burkitt's Lymphoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.3056
p.E91G	SIDM00793	Burkitt's Lymphoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.3056
p.E91G	SIDM00863	Burkitt's Lymphoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.3056
p.E103K	SIDM00832	Colorectal Carcinoma	GDSC	LPPTPGTE	DEG_SCF_FBW7_2	0.2222
p.E103K	ACH-000680	Colon/Colorectal Cancer	CCLE	LPPTPGTE	DEG_SCF_FBW7_2	0.2222
p.E103K	SW948	large_intestine	COSMIC	LPPTPGTE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPPTPGTE

Degron related mutations and impact score

Drug responses associated with TMEM247 mutations

All proteins holding degron of LPPTPGTE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NEH6	Transmembrane protein 247	DEG_SCF_FBW7_2	92:99	LPPTPGTE	FBXW7	0.8858	More...