DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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MROH2A
UniProt ID:
A6NES4
Entrez ID:
Protein name:
Maestro heat-like repeat-containing protein family member 2A (HEAT repeat-containing protein 7B1)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
cytoplasm [GO:0005737]...
cytoplasm [GO:0005737]
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Open in full screen with detailed sequence annotations
MROH2A
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.E1284K
DO222491
MELA
ICGC
VHTTPLPE
DEG_SCF_FBW7_2
1276:1283
Mutation rewiring degron network
0.3056
p.P1283A
SIDM01174
Cervical Carcinoma
GDSC
VHTTPLPE
DEG_SCF_FBW7_2
1276:1283
Mutation altering degron motif
0.7503
p.P1283A
SW756
cervix
COSMIC
VHTTPLPE
DEG_SCF_FBW7_2
1276:1283
Mutation altering degron motif
0.7503
p.P1280A
ACH-001402
Cervical Cancer
CCLE
VHTTPLPE
DEG_SCF_FBW7_2
1276:1283
Mutation altering degron motif
0.7503
p.P1280A
SW756
cervix
COSMIC
VHTTPLPE
DEG_SCF_FBW7_2
1276:1283
Mutation altering degron motif
0.7503
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for MROH2A in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc