DegronMD

Uniprot ID: A6NES4

Source protein: Maestro heat-like repeat-containing protein family member 2A

Source gene: MROH2A

Class: DEG_SCF_FBW7_2

Location: 1276:1283

E3 ligase: FBXW7

DEGRON score: 0.6976

ASA_SCORE: 87.8125

COIL: 0.7926

CONS_SCORE: 0.3094

DSS_SCORE: 0.2079

HELIX: 0.1474

FCONS_SCORE: 1.2095

RIG_SCORE: 0.7967

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1284K	DO222491	MELA	ICGC	VHTTPLPE	DEG_SCF_FBW7_2	0.3056
p.P1283A	SIDM01174	Cervical Carcinoma	GDSC	VHTTPLPE	DEG_SCF_FBW7_2	0.7503
p.P1283A	SW756	cervix	COSMIC	VHTTPLPE	DEG_SCF_FBW7_2	0.7503
p.P1280A	ACH-001402	Cervical Cancer	CCLE	VHTTPLPE	DEG_SCF_FBW7_2	0.7503
p.P1280A	SW756	cervix	COSMIC	VHTTPLPE	DEG_SCF_FBW7_2	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NES4	Maestro heat-like repeat-containing protein family member 2A	DEG_SCF_FBW7_2	1276:1283	VHTTPLPE	FBXW7	0.6976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons