DegronMD - A6NEV1(PRR23A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R260S	TCGA-AA-3877	COAD	TCGA	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation altering degron motif	0.7427
p.R260S	DO7855	COAD	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation altering degron motif	0.7427
p.R260H	TCGA-D1-A163	UCEC	TCGA	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation altering degron motif	0.8244
p.R260H	DO41008	UCEC	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation altering degron motif	0.8244
p.P252Q	TCGA-LN-A49Y	ESCA	TCGA	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation rewiring degron network	0.1111
p.R262L	TCGA-O2-A52V	LUSC	TCGA	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation altering degron motif	0.7316
p.R262L	DO219223	LUSC	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation altering degron motif	0.7316
p.P256L	TCGA-QC-A7B5	SARC	TCGA	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation rewiring degron network	0.2222
p.P256L	DO220239	SARC	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation rewiring degron network	0.2222
p.P252L	DO222860	COCA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation rewiring degron network	0.1111
p.R260C	DO233267	GACA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation altering degron motif	0.8301
p.R260C	SIDM00006	Other Solid Cancers	GDSC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation altering degron motif	0.8301
p.R260C	MCC26	skin	COSMIC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation altering degron motif	0.8301
p.Q265K	DO229024	LICA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation altering degron motif	0.5833
p.F264L	DO229041	LICA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation altering degron motif	0.6981
p.P255S	DO222731	MELA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation rewiring degron network	0.1944
p.R254C	DO33016	PACA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation rewiring degron network	0.1667
p.Q265H	DO232224	PBCA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation altering degron motif	0.647
p.R254H	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation rewiring degron network	0.1667
p.R254H	ACH-000888	Lung Cancer	CCLE	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation rewiring degron network	0.1667
p.E266G	ACH-001197	Lymphoma	CCLE	RRRLFQE	LIG_APCC_ABBAyCdc20_2	260:266	Mutation altering degron motif	0.7199

Kaplan plot for PRR23A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRR23A

UniProt ID: A6NEV1

Entrez ID: 729627

Protein name: Proline-rich protein 23A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRR23A in