DegronMD

Uniprot ID: A6NEV1

Source protein: Proline-rich protein 23A

Source gene: PRR23A

Class: LIG_APCC_ABBAyCdc20_2

Location: 260:266

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9828

ASA_SCORE: 117.4286

COIL: 0.4017

CONS_SCORE: 0.7839

DSS_SCORE: 0.9313

HELIX: 0.5567

FCONS_SCORE: 1.3927

RIG_SCORE: 0.747

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R260S	TCGA-AA-3877	COAD	TCGA	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.7427
p.R260S	DO7855	COAD	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.7427
p.R260H	TCGA-D1-A163	UCEC	TCGA	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R260H	DO41008	UCEC	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.8244
p.P252Q	TCGA-LN-A49Y	ESCA	TCGA	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R262L	TCGA-O2-A52V	LUSC	TCGA	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.7316
p.R262L	DO219223	LUSC	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.7316
p.P256L	TCGA-QC-A7B5	SARC	TCGA	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P256L	DO220239	SARC	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P252L	DO222860	COCA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R260C	DO233267	GACA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R260C	SIDM00006	Other Solid Cancers	GDSC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R260C	MCC26	skin	COSMIC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.8301
p.Q265K	DO229024	LICA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.5833
p.F264L	DO229041	LICA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.6981
p.P255S	DO222731	MELA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R254C	DO33016	PACA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.1667
p.Q265H	DO232224	PBCA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.647
p.R254H	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R254H	ACH-000888	Lung Cancer	CCLE	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E266G	ACH-001197	Lymphoma	CCLE	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.7199

DegronMD: protein-targeted degradation, mutation and drug response to degrons