DegronMD

Uniprot ID: Q6ZRP0

Source protein: Proline-rich protein 23C

Source gene: PRR23C

Class: LIG_APCC_ABBAyCdc20_2

Location: 256:262

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9818

ASA_SCORE: 115.4429

COIL: 0.4344

CONS_SCORE: 0.7602

DSS_SCORE: 0.8918

HELIX: 0.4941

FCONS_SCORE: 1.2666

RIG_SCORE: 0.7648

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R250H	DO225232	BRCA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R258S	DO229045	LICA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.6316
p.L247I	DO23134	LINC	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R258H	DO52675	MALY	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.7133
p.P251S	DO220853	MELA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.RP250RS	DO220853	MELA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0
p.E249K	SIDM00080	Melanoma	GDSC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E249K	ACH-000730	Skin Cancer	CCLE	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R258C	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.719
p.E262K	SIDM00909	Melanoma	GDSC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E262K	ACH-000644	Skin Cancer	CCLE	RRRLFQE	LIG_APCC_ABBAyCdc20_2	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons