DegronMD - Q6ZRP0(PRR23C)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P188L	TCGA-66-2791	LUSC	TCGA	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.6471
p.P188L	DO26435	LUSC	ICGC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.6471
p.G192D	TCGA-69-7979	LUAD	TCGA	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.3056
p.G192D	DO23874	LUAD	ICGC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.3056
p.S187N	TCGA-78-7154	LUAD	TCGA	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.5958
p.S187N	TCGA-ER-A19M	SKCM	TCGA	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.5958
p.S187N	DO24070	LUAD	ICGC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.5958
p.S187N	DO37798	SKCM	ICGC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.5958
p.R190L	TCGA-BQ-7059	KIRP	TCGA	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.7316
p.R190L	DO20932	KIRP	ICGC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.7316
p.A182T	TCGA-D1-A103	UCEC	TCGA	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.2222
p.A182T	DO42312	UCEC	ICGC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.2222
p.P180S	TCGA-GN-A8LK	SKCM	TCGA	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.1667
p.P180S	DO51259	SKCM	ICGC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.1667
p.R195Q	TCGA-Z2-A8RT	SKCM	TCGA	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.2222
p.R195Q	DO222472	ESCA	ICGC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.2222
p.R195Q	DO233855	GACA	ICGC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.2222
p.R195Q	DO51301	SKCM	ICGC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.2222
p.R195Q	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.2222
p.R195Q	ACH-000603	Lung Cancer	CCLE	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.2222
p.R195Q	BEN	lung	COSMIC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.2222
p.R190W	DO868	BOCA	ICGC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.7523
p.R190W	DO50439	ESAD	ICGC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.7523
p.R190W	DO222390	MELA	ICGC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.7523
p.R250H	DO225232	BRCA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	256:262	Mutation rewiring degron network	0.1667
p.A182D	DO228986	LICA	ICGC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.2222
p.R258S	DO229045	LICA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	256:262	Mutation altering degron motif	0.6316
p.L247I	DO23134	LINC	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	256:262	Mutation rewiring degron network	0.0833
p.R258H	DO52675	MALY	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	256:262	Mutation altering degron motif	0.7133
p.P251S	DO220853	MELA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	256:262	Mutation rewiring degron network	0.1944
p.RP250RS	DO220853	MELA	ICGC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	256:262	Mutation rewiring degron network	0
p.P193L	DO220906	MELA	ICGC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.2778
p.R190Q	DO224776	PACA	ICGC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation altering degron motif	0.6218
p.A176T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.0556
p.A176T	ACH-000920	Leukemia	CCLE	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.0556
p.A176T	CML-T1	haematopoietic and lymphoid tissue	COSMIC	FSPYRE	LIG_APCC_ABBA_1	186:191	Mutation rewiring degron network	0.0556
p.E249K	SIDM00080	Melanoma	GDSC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	256:262	Mutation rewiring degron network	0.1389
p.E249K	ACH-000730	Skin Cancer	CCLE	RRRLFQE	LIG_APCC_ABBAyCdc20_2	256:262	Mutation rewiring degron network	0.1389
p.R258C	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	256:262	Mutation altering degron motif	0.719
p.E262K	SIDM00909	Melanoma	GDSC	RRRLFQE	LIG_APCC_ABBAyCdc20_2	256:262	Mutation altering degron motif	0.7022
p.E262K	ACH-000644	Skin Cancer	CCLE	RRRLFQE	LIG_APCC_ABBAyCdc20_2	256:262	Mutation altering degron motif	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRR23C

UniProt ID: Q6ZRP0

Entrez ID: 389152

Protein name: Proline-rich protein 23C

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRR23C in