DegronMD

Uniprot ID: Q6ZRP0

Source protein: Proline-rich protein 23C

Source gene: PRR23C

Class: LIG_APCC_ABBA_1

Location: 186:191

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9133

ASA_SCORE: 76.3833

COIL: 0.853

CONS_SCORE: 0.3374

DSS_SCORE: 0.3886

HELIX: 0.0695

FCONS_SCORE: 0.9209

RIG_SCORE: 0.6746

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P188L	TCGA-66-2791	LUSC	TCGA	FSPYRE	LIG_APCC_ABBA_1	0.6471
p.P188L	DO26435	LUSC	ICGC	FSPYRE	LIG_APCC_ABBA_1	0.6471
p.G192D	TCGA-69-7979	LUAD	TCGA	FSPYRE	LIG_APCC_ABBA_1	0.3056
p.G192D	DO23874	LUAD	ICGC	FSPYRE	LIG_APCC_ABBA_1	0.3056
p.S187N	TCGA-78-7154	LUAD	TCGA	FSPYRE	LIG_APCC_ABBA_1	0.5958
p.S187N	TCGA-ER-A19M	SKCM	TCGA	FSPYRE	LIG_APCC_ABBA_1	0.5958
p.S187N	DO24070	LUAD	ICGC	FSPYRE	LIG_APCC_ABBA_1	0.5958
p.S187N	DO37798	SKCM	ICGC	FSPYRE	LIG_APCC_ABBA_1	0.5958
p.R190L	TCGA-BQ-7059	KIRP	TCGA	FSPYRE	LIG_APCC_ABBA_1	0.7316
p.R190L	DO20932	KIRP	ICGC	FSPYRE	LIG_APCC_ABBA_1	0.7316
p.A182T	TCGA-D1-A103	UCEC	TCGA	FSPYRE	LIG_APCC_ABBA_1	0.2222
p.A182T	DO42312	UCEC	ICGC	FSPYRE	LIG_APCC_ABBA_1	0.2222
p.P180S	TCGA-GN-A8LK	SKCM	TCGA	FSPYRE	LIG_APCC_ABBA_1	0.1667
p.P180S	DO51259	SKCM	ICGC	FSPYRE	LIG_APCC_ABBA_1	0.1667
p.R195Q	TCGA-Z2-A8RT	SKCM	TCGA	FSPYRE	LIG_APCC_ABBA_1	0.2222
p.R195Q	DO222472	ESCA	ICGC	FSPYRE	LIG_APCC_ABBA_1	0.2222
p.R195Q	DO233855	GACA	ICGC	FSPYRE	LIG_APCC_ABBA_1	0.2222
p.R195Q	DO51301	SKCM	ICGC	FSPYRE	LIG_APCC_ABBA_1	0.2222
p.R195Q	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	FSPYRE	LIG_APCC_ABBA_1	0.2222
p.R195Q	ACH-000603	Lung Cancer	CCLE	FSPYRE	LIG_APCC_ABBA_1	0.2222
p.R195Q	BEN	lung	COSMIC	FSPYRE	LIG_APCC_ABBA_1	0.2222
p.R190W	DO868	BOCA	ICGC	FSPYRE	LIG_APCC_ABBA_1	0.7523
p.R190W	DO50439	ESAD	ICGC	FSPYRE	LIG_APCC_ABBA_1	0.7523
p.R190W	DO222390	MELA	ICGC	FSPYRE	LIG_APCC_ABBA_1	0.7523
p.A182D	DO228986	LICA	ICGC	FSPYRE	LIG_APCC_ABBA_1	0.2222
p.P193L	DO220906	MELA	ICGC	FSPYRE	LIG_APCC_ABBA_1	0.2778
p.R190Q	DO224776	PACA	ICGC	FSPYRE	LIG_APCC_ABBA_1	0.6218
p.A176T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	FSPYRE	LIG_APCC_ABBA_1	0.0556
p.A176T	ACH-000920	Leukemia	CCLE	FSPYRE	LIG_APCC_ABBA_1	0.0556
p.A176T	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	FSPYRE	LIG_APCC_ABBA_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FSPYRE

Degron related mutations and impact score

Drug responses associated with PRR23C mutations

All proteins holding degron of FSPYRE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRP0	Proline-rich protein 23C	LIG_APCC_ABBA_1	186:191	FSPYRE	APC,CDC20,FZR1	0.9133	More...