DegronMD - A6NFA1(TRABD2B)

TRABD2B

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A488T	DO230311	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	487:491	Mutation altering degron motif	0.6028
p.D477H	DO48482	KIRP	ICGC	PASSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.0556
p.P437L	DO23509	LIRI	ICGC	FNDLWVRI	DEG_MDM2_SWIB_1	440:447	Mutation rewiring degron network	0.25
p.P499L	DO220891	MELA	ICGC	PASSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.1111
p.E448K	DO222434	MELA	ICGC	FNDLWVRI	DEG_MDM2_SWIB_1	440:447	Mutation rewiring degron network	0.3056
p.P456T	DO46473	OV	ICGC	FNDLWVRI	DEG_MDM2_SWIB_1	440:447	Mutation rewiring degron network	0.0833
p.S432R	DO38404	STAD	ICGC	FNDLWVRI	DEG_MDM2_SWIB_1	440:447	Mutation rewiring degron network	0.1111
p.R436Q	SIDM00121	T-Lymphoblastic Leukemia	GDSC	FNDLWVRI	DEG_MDM2_SWIB_1	440:447	Mutation rewiring degron network	0.2222
p.R436Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	FNDLWVRI	DEG_MDM2_SWIB_1	440:447	Mutation rewiring degron network	0.2222
p.Q482R	ACH-000994	Endometrial/Uterine Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.1944
p.P493H	ACH-001960	Bile Duct Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc