DegronMD

Uniprot ID: A6NFA1

Source protein: Metalloprotease TIKI2

Source gene: TRABD2B

Class: DEG_MDM2_SWIB_1

Location: 440:447

E3 ligase: MDM2

DEGRON score: 0.8922

ASA_SCORE: 46.375

COIL: 0.38

CONS_SCORE: 0.4089

DSS_SCORE: 0.5672

HELIX: 0.1766

FCONS_SCORE: 1.6575

RIG_SCORE: 0.7833

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P437L	DO23509	LIRI	ICGC	FNDLWVRI	DEG_MDM2_SWIB_1	0.25
p.E448K	DO222434	MELA	ICGC	FNDLWVRI	DEG_MDM2_SWIB_1	0.3056
p.P456T	DO46473	OV	ICGC	FNDLWVRI	DEG_MDM2_SWIB_1	0.0833
p.S432R	DO38404	STAD	ICGC	FNDLWVRI	DEG_MDM2_SWIB_1	0.1111
p.R436Q	SIDM00121	T-Lymphoblastic Leukemia	GDSC	FNDLWVRI	DEG_MDM2_SWIB_1	0.2222
p.R436Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	FNDLWVRI	DEG_MDM2_SWIB_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NFA1	Metalloprotease TIKI2	DEG_MDM2_SWIB_1	440:447	FNDLWVRI	MDM2	0.8922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons