DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
IGLON5
UniProt ID:
A6NGN9
Entrez ID:
402665
Protein name:
IgLON family member 5
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
extracellular region [GO:0005576]...
extracellular region [GO:0005576]
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Choose a PDB ID:
6DLD
6DLE
Open in full screen with detailed sequence annotations
IGLON5
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TCGA
ICGC
COSMIC
CCLE
GDSC
Show Degron:
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Phosphorylation
Legend: PTM sites
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.S225R
TCGA-39-5034
LUSC
TCGA
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation rewiring degron network
0.0556
p.S225R
DO26854
LUSC
ICGC
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation rewiring degron network
0.0556
p.R209H
TCGA-AJ-A3BG
UCEC
TCGA
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation altering degron motif
0.7133
p.R209H
DO42633
UCEC
ICGC
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation altering degron motif
0.7133
p.L211P
TCGA-AJ-A3IA
UCEC
TCGA
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation altering degron motif
0.7582
p.L211P
DO43082
UCEC
ICGC
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation altering degron motif
0.7582
p.S203L
TCGA-AP-A1E0
UCEC
TCGA
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation rewiring degron network
0.2222
p.S203L
DO43154
UCEC
ICGC
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation rewiring degron network
0.2222
p.A204V
TCGA-BC-A10Z
LIHC
TCGA
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation rewiring degron network
0.25
p.A204V
TCGA-L5-A4OR
ESCA
TCGA
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation rewiring degron network
0.25
p.A204V
DO23043
LIHC
ICGC
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation rewiring degron network
0.25
p.P218L
TCGA-CD-A4MG
STAD
TCGA
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation rewiring degron network
0.25
p.P218L
DO230347
COCA
ICGC
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation rewiring degron network
0.25
p.P218L
DO48009
STAD
ICGC
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation rewiring degron network
0.25
p.V223M
DO233869
GACA
ICGC
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation rewiring degron network
0.1111
p.L211M
DO232224
PBCA
ICGC
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation altering degron motif
0.711
p.D206E
SIDM00114
Non-Small Cell Lung Carcinoma
GDSC
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation rewiring degron network
0.3056
p.D206E
H513
pleura
COSMIC
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation rewiring degron network
0.3056
p.D206N
ACH-001412
Bladder Cancer
CCLE
SRRVLVTVN
DEG_APCC_DBOX_1
207:215
Mutation rewiring degron network
0.3056
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for IGLON5 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc