DegronMD

Uniprot ID: A6NGN9

Source protein: IgLON family member 5

Source gene: IGLON5

Class: DEG_APCC_DBOX_1

Location: 207:215

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9111

ASA_SCORE: 60.8667

COIL: 0.0567

CONS_SCORE: 0.9532

DSS_SCORE: 0.3864

HELIX: 0.0033

FCONS_SCORE: 0.9718

RIG_SCORE: 0.8111

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S225R	TCGA-39-5034	LUSC	TCGA	SRRVLVTVN	DEG_APCC_DBOX_1	0.0556
p.S225R	DO26854	LUSC	ICGC	SRRVLVTVN	DEG_APCC_DBOX_1	0.0556
p.R209H	TCGA-AJ-A3BG	UCEC	TCGA	SRRVLVTVN	DEG_APCC_DBOX_1	0.7133
p.R209H	DO42633	UCEC	ICGC	SRRVLVTVN	DEG_APCC_DBOX_1	0.7133
p.L211P	TCGA-AJ-A3IA	UCEC	TCGA	SRRVLVTVN	DEG_APCC_DBOX_1	0.7582
p.L211P	DO43082	UCEC	ICGC	SRRVLVTVN	DEG_APCC_DBOX_1	0.7582
p.S203L	TCGA-AP-A1E0	UCEC	TCGA	SRRVLVTVN	DEG_APCC_DBOX_1	0.2222
p.S203L	DO43154	UCEC	ICGC	SRRVLVTVN	DEG_APCC_DBOX_1	0.2222
p.A204V	TCGA-BC-A10Z	LIHC	TCGA	SRRVLVTVN	DEG_APCC_DBOX_1	0.25
p.A204V	TCGA-L5-A4OR	ESCA	TCGA	SRRVLVTVN	DEG_APCC_DBOX_1	0.25
p.A204V	DO23043	LIHC	ICGC	SRRVLVTVN	DEG_APCC_DBOX_1	0.25
p.P218L	TCGA-CD-A4MG	STAD	TCGA	SRRVLVTVN	DEG_APCC_DBOX_1	0.25
p.P218L	DO230347	COCA	ICGC	SRRVLVTVN	DEG_APCC_DBOX_1	0.25
p.P218L	DO48009	STAD	ICGC	SRRVLVTVN	DEG_APCC_DBOX_1	0.25
p.V223M	DO233869	GACA	ICGC	SRRVLVTVN	DEG_APCC_DBOX_1	0.1111
p.L211M	DO232224	PBCA	ICGC	SRRVLVTVN	DEG_APCC_DBOX_1	0.711
p.D206E	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SRRVLVTVN	DEG_APCC_DBOX_1	0.3056
p.D206E	H513	pleura	COSMIC	SRRVLVTVN	DEG_APCC_DBOX_1	0.3056
p.D206N	ACH-001412	Bladder Cancer	CCLE	SRRVLVTVN	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NGN9	IgLON family member 5	DEG_APCC_DBOX_1	207:215	SRRVLVTVN	APC,CDC20,FZR1	0.9111	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons