CAPN8
UniProt ID: A6NHC0
Entrez ID: 388743
Protein name: Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By simil...
FUNCTION: Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity). {ECO:0000250}.
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GO - Biological processes (BP):
digestion [GO:0007586]; proteolysis [GO:0006508]...
digestion [GO:0007586]; proteolysis [GO:0006508]
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GO - Molecular function (MF):
calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; calcium ion binding [GO:0005509]...
calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; calcium ion binding [GO:0005509]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]...
cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]
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CAPN8
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*NOTE: the Kaplan plots were collected from OncoLnc