DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
FEPFKD
Uniprot ID:
A6NHC0
Source protein:
Calpain-8
Source gene:
CAPN8
Class:
LIG_APCC_ABBA_1
Location:
491:496
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6001
ASA_SCORE:
78.1
COIL:
0.8048
CONS_SCORE:
0.6565
DSS_SCORE:
0.1309
HELIX:
0.0283
FCONS_SCORE:
1.0121
RIG_SCORE:
0.8225
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R495H
DO228696
EOPC
ICGC
FEPFKD
LIG_APCC_ABBA_1
0.8244
p.E498K
SIDM01293
Colorectal Carcinoma
GDSC
FEPFKD
LIG_APCC_ABBA_1
0.2778
Drug responses associated with CAPN8 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FEPFKD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NHC0
Calpain-8
LIG_APCC_ABBA_1
491:496
FEPFKD
APC,CDC20,FZR1
0.6001
More...