DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
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POTEM
UniProt ID:
A6NI47
Entrez ID:
641455
Protein name:
Putative POTE ankyrin domain family member M
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Open in full screen with detailed sequence annotations
POTEM
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Legend: PTM sites
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.K190Q
DO229030
LICA
ICGC
RRCQLNILD
DEG_APCC_DBOX_1
195:203
Mutation substituting flanking lysine
0.3056
p.A213P
NCI-H345
lung
COSMIC
RRCQLNILD
DEG_APCC_DBOX_1
195:203
Mutation rewiring degron network
0.0556
p.R196L
NCI-H1435
lung
COSMIC
RRCQLNILD
DEG_APCC_DBOX_1
195:203
Mutation altering degron motif
0.8428
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for POTEM in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc