DegronMD

Uniprot ID: A6NI47

Source protein: Putative POTE ankyrin domain family member M

Source gene: POTEM

Class: DEG_APCC_DBOX_1

Location: 195:203

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5304

ASA_SCORE: 65.5889

COIL: 0.8114

CONS_SCORE: 0.5239

DSS_SCORE: 0.0957

HELIX: 0.0604

FCONS_SCORE: 0.8867

RIG_SCORE: 0.876

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K190Q	DO229030	LICA	ICGC	RRCQLNILD	DEG_APCC_DBOX_1	0.3056
p.A213P	NCI-H345	lung	COSMIC	RRCQLNILD	DEG_APCC_DBOX_1	0.0556
p.R196L	NCI-H1435	lung	COSMIC	RRCQLNILD	DEG_APCC_DBOX_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6S5H5	POTE ankyrin domain family member G	DEG_APCC_DBOX_1	195:203	RRCQLNILD	APC,CDC20,FZR1	0.7283	More...
A6NI47	Putative POTE ankyrin domain family member M	DEG_APCC_DBOX_1	195:203	RRCQLNILD	APC,CDC20,FZR1	0.5304	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons