DegronMD

Uniprot ID: Q6S5H5

Source protein: POTE ankyrin domain family member G

Source gene: POTEG

Class: DEG_APCC_DBOX_1

Location: 195:203

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7283

ASA_SCORE: 68.5778

COIL: 0.7859

CONS_SCORE: 0.5456

DSS_SCORE: 0.0963

HELIX: 0.059

FCONS_SCORE: 0.8119

RIG_SCORE: 0.8774

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A213S	TCGA-68-7757	LUSC	TCGA	RRCQLNILD	DEG_APCC_DBOX_1	0.0556
p.A213S	DO26886	LUSC	ICGC	RRCQLNILD	DEG_APCC_DBOX_1	0.0556
p.I201V	DO51035	LAML	ICGC	RRCQLNILD	DEG_APCC_DBOX_1	0.5965
p.I201V	DO52363	LUSC	ICGC	RRCQLNILD	DEG_APCC_DBOX_1	0.5965
p.I201V	DO52361	LUSC	ICGC	RRCQLNILD	DEG_APCC_DBOX_1	0.5965
p.I201V	DO52381	LUSC	ICGC	RRCQLNILD	DEG_APCC_DBOX_1	0.5965
p.A213V	DO36556	READ	ICGC	RRCQLNILD	DEG_APCC_DBOX_1	0.0556
p.A213V	DO229253	THCA	ICGC	RRCQLNILD	DEG_APCC_DBOX_1	0.0556
p.A213P	SIDM00719	Small Cell Lung Carcinoma	GDSC	RRCQLNILD	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6S5H5	POTE ankyrin domain family member G	DEG_APCC_DBOX_1	195:203	RRCQLNILD	APC,CDC20,FZR1	0.7283	More...
A6NI47	Putative POTE ankyrin domain family member M	DEG_APCC_DBOX_1	195:203	RRCQLNILD	APC,CDC20,FZR1	0.5304	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons