DegronMD - A6NI56(CCDC154)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A367V	TCGA-A6-5665	COAD	TCGA	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation rewiring degron network	0.1111
p.A367V	DO9756	COAD	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation rewiring degron network	0.1111
p.E381K	DO234462	ESAD	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation altering degron motif	0.7022
p.A376E	DO233671	GACA	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation altering degron motif	0.7701
p.Q377K	DO228976	LICA	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation altering degron motif	0.6944
p.A383D	DO228978	LICA	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation rewiring degron network	0.2778
p.A383D	DO229006	LICA	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation rewiring degron network	0.2778
p.L373M	DO229025	LICA	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation rewiring degron network	0.2778
p.A366D	DO229034	LICA	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation rewiring degron network	0.0833
p.A366D	DO229045	LICA	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation rewiring degron network	0.0833
p.R384G	DO26553	LUSC	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation rewiring degron network	0.25
p.R384W	DO49448	PACA	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation rewiring degron network	0.25
p.L378P	SIDM00329	Hodgkin's Lymphoma	GDSC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation altering degron motif	0.7582
p.L378P	L-540	haematopoietic and lymphoid tissue	COSMIC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation altering degron motif	0.7582
p.A366T	SIDM00498	Colorectal Carcinoma	GDSC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation rewiring degron network	0.0833
p.A366T	ACH-000970	Colon/Colorectal Cancer	CCLE	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation rewiring degron network	0.0833
p.A366T	SNU-C5	large intestine	COSMIC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation rewiring degron network	0.0833
p.Q377E	ACH-000573	Breast Cancer	CCLE	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation altering degron motif	0.6744
p.T390M	NCI-H211	lung	COSMIC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation rewiring degron network	0.0833
p.V369M	KE-37	haematopoietic and lymphoid tissue	COSMIC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation rewiring degron network	0.1667
p.G386D	OVTOKO	ovary	COSMIC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	375:381	Mutation rewiring degron network	0.1944

Kaplan plot for CCDC154 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC154

UniProt ID: A6NI56

Entrez ID: 645811

Protein name: Coiled-coil domain-containing protein 154

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC154 in