DegronMD

Uniprot ID: A6NI56

Source protein: Coiled-coil domain-containing protein 154

Source gene: CCDC154

Class: LIG_APCC_ABBAyCdc20_2

Location: 375:381

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8296

ASA_SCORE: 112.6571

COIL: 0.1306

CONS_SCORE: 0.5735

DSS_SCORE: 0.2534

HELIX: 0.8711

FCONS_SCORE: 1.266

RIG_SCORE: 0.7792

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A367V	TCGA-A6-5665	COAD	TCGA	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.A367V	DO9756	COAD	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E381K	DO234462	ESAD	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.7022
p.A376E	DO233671	GACA	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.7701
p.Q377K	DO228976	LICA	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.6944
p.A383D	DO228978	LICA	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.A383D	DO229006	LICA	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L373M	DO229025	LICA	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.A366D	DO229034	LICA	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A366D	DO229045	LICA	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R384G	DO26553	LUSC	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.25
p.R384W	DO49448	PACA	ICGC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.25
p.L378P	SIDM00329	Hodgkin's Lymphoma	GDSC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.7582
p.L378P	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.7582
p.A366T	SIDM00498	Colorectal Carcinoma	GDSC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A366T	ACH-000970	Colon/Colorectal Cancer	CCLE	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A366T	SNU-C5	large_intestine	COSMIC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.Q377E	ACH-000573	Breast Cancer	CCLE	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.6744
p.T390M	NCI-H211	lung	COSMIC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V369M	KE-37	haematopoietic_and_lymphoid_tissue	COSMIC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G386D	OVTOKO	ovary	COSMIC	RQEMHGE	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NI56	Coiled-coil domain-containing protein 154	LIG_APCC_ABBAyCdc20_2	375:381	RQEMHGE	APC,CDC20,FZR1	0.8296	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons