DegronMD - A6NI79(CCDC69)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A295P	TCGA-46-6025	LUSC	TCGA	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.1667
p.A295P	DO26644	LUSC	ICGC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.1667
p.A280T	TCGA-CM-4746	COAD	TCGA	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.3056
p.A280T	DO7882	COAD	ICGC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.3056
p.A275V	TCGA-D1-A1NY	UCEC	TCGA	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.1667
p.A275V	DO42512	UCEC	ICGC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.1667
p.V291I	TCGA-EW-A1PB	BRCA	TCGA	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.2778
p.V291I	DO4695	BRCA	ICGC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.2778
p.A284V	DO233272	GACA	ICGC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation altering degron motif	0.6936
p.A275D	DO229006	LICA	ICGC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.1667
p.V272I	SIDM00672	Hepatocellular Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.0833
p.V272I	SIDM01090	Colorectal Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.0833
p.V272I	SIDM00633	Breast Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.0833
p.V272I	SIDM00878	Breast Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.0833
p.V272I	SIDM00181	Bladder Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.0833
p.V272I	SIDM00032	Bladder Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.0833
p.V272I	SIDM01646	Non-Cancerous	GDSC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.0833
p.V272I	SIDM00930	Osteosarcoma	GDSC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.0833
p.V272I	SIDM00954	Breast Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.0833
p.V272I	SIDM01681	Non-Cancerous	GDSC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.0833
p.V272I	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.0833
p.V272I	SIDM00721	Small Cell Lung Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.0833
p.V272I	SIDM00808	Burkitt's Lymphoma	GDSC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.0833
p.V272I	SIDM01254	Burkitt's Lymphoma	GDSC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.0833
p.L273I	SIDM00217	Colorectal Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.1111
p.L273I	SNU-1040	large intestine	COSMIC	FPLAPVTPT	DEG_SIAH_1	281:289	Mutation rewiring degron network	0.1111

Kaplan plot for CCDC69 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC69

UniProt ID: A6NI79

Entrez ID: 26112

Protein name: Coiled-coil domain-containing protein 69

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC69 in