DegronMD

Uniprot ID: A6NI79

Source protein: Coiled-coil domain-containing protein 69

Source gene: CCDC69

Class: DEG_SIAH_1

Location: 281:289

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.973

ASA_SCORE: 89.5667

COIL: 0.9458

CONS_SCORE: 0.5953

DSS_SCORE: 0.2856

HELIX: 0.0167

FCONS_SCORE: 1.0244

RIG_SCORE: 0.7483

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A295P	TCGA-46-6025	LUSC	TCGA	FPLAPVTPT	DEG_SIAH_1	0.1667
p.A295P	DO26644	LUSC	ICGC	FPLAPVTPT	DEG_SIAH_1	0.1667
p.A280T	TCGA-CM-4746	COAD	TCGA	FPLAPVTPT	DEG_SIAH_1	0.3056
p.A280T	DO7882	COAD	ICGC	FPLAPVTPT	DEG_SIAH_1	0.3056
p.A275V	TCGA-D1-A1NY	UCEC	TCGA	FPLAPVTPT	DEG_SIAH_1	0.1667
p.A275V	DO42512	UCEC	ICGC	FPLAPVTPT	DEG_SIAH_1	0.1667
p.V291I	TCGA-EW-A1PB	BRCA	TCGA	FPLAPVTPT	DEG_SIAH_1	0.2778
p.V291I	DO4695	BRCA	ICGC	FPLAPVTPT	DEG_SIAH_1	0.2778
p.A284V	DO233272	GACA	ICGC	FPLAPVTPT	DEG_SIAH_1	0.6936
p.A275D	DO229006	LICA	ICGC	FPLAPVTPT	DEG_SIAH_1	0.1667
p.V272I	SIDM00672	Hepatocellular Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	0.0833
p.V272I	SIDM01090	Colorectal Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	0.0833
p.V272I	SIDM00633	Breast Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	0.0833
p.V272I	SIDM00878	Breast Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	0.0833
p.V272I	SIDM00181	Bladder Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	0.0833
p.V272I	SIDM00032	Bladder Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	0.0833
p.V272I	SIDM01646	Non-Cancerous	GDSC	FPLAPVTPT	DEG_SIAH_1	0.0833
p.V272I	SIDM00930	Osteosarcoma	GDSC	FPLAPVTPT	DEG_SIAH_1	0.0833
p.V272I	SIDM00954	Breast Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	0.0833
p.V272I	SIDM01681	Non-Cancerous	GDSC	FPLAPVTPT	DEG_SIAH_1	0.0833
p.V272I	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	0.0833
p.V272I	SIDM00721	Small Cell Lung Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	0.0833
p.V272I	SIDM00808	Burkitt's Lymphoma	GDSC	FPLAPVTPT	DEG_SIAH_1	0.0833
p.V272I	SIDM01254	Burkitt's Lymphoma	GDSC	FPLAPVTPT	DEG_SIAH_1	0.0833
p.L273I	SIDM00217	Colorectal Carcinoma	GDSC	FPLAPVTPT	DEG_SIAH_1	0.1111
p.L273I	SNU-1040	large_intestine	COSMIC	FPLAPVTPT	DEG_SIAH_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NI79	Coiled-coil domain-containing protein 69	DEG_SIAH_1	281:289	FPLAPVTPT	SIAH1,SIAH2,SIAH3	0.973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FPLAPVTPT

Degron related mutations and impact score

Drug responses associated with CCDC69 mutations

All proteins holding degron of FPLAPVTPT