DegronMD - A6NJG2(SOWAHD)

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
RRGALRELL	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Ankyrin repeat domain-containing protein SOWAHD	70:78	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R71L	DO229056	LICA	ICGC	RRGALRELL	DEG_APCC_DBOX_1	70:78	Mutation altering degron motif	0.8428
p.R75Q	DO232481	PBCA	ICGC	RRGALRELL	DEG_APCC_DBOX_1	70:78	Mutation altering degron motif	0.6218
p.A73V	SIDM02080	Pancreatic Carcinoma	GDSC	RRGALRELL	DEG_APCC_DBOX_1	70:78	Mutation altering degron motif	0.5825
p.R69S	DO27453	LUSC	ICGC	RRGALRELL	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.3056
p.P85S	DO220906	MELA	ICGC	RRGALRELL	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons