DegronMD

Uniprot ID: A6NJG2

Source protein: Ankyrin repeat domain-containing protein SOWAHD

Source gene: SOWAHD

Class: DEG_APCC_DBOX_1

Location: 70:78

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5273

ASA_SCORE: 101.5889

COIL: 0.3596

CONS_SCORE: 0.8072

DSS_SCORE: 0.454

HELIX: 0.6258

FCONS_SCORE: 1.0228

RIG_SCORE: 0.7482

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R71L	DO229056	LICA	ICGC	RRGALRELL	DEG_APCC_DBOX_1	0.8428
p.R69S	DO27453	LUSC	ICGC	RRGALRELL	DEG_APCC_DBOX_1	0.3056
p.P85S	DO220906	MELA	ICGC	RRGALRELL	DEG_APCC_DBOX_1	0.1389
p.R75Q	DO232481	PBCA	ICGC	RRGALRELL	DEG_APCC_DBOX_1	0.6218
p.A73V	SIDM02080	Pancreatic Carcinoma	GDSC	RRGALRELL	DEG_APCC_DBOX_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NJG2	Ankyrin repeat domain-containing protein SOWAHD	DEG_APCC_DBOX_1	70:78	RRGALRELL	APC,CDC20,FZR1	0.5273	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons