DegronMD - A6NJG6(ARGFX)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S169T	TCGA-13-2059	OV	TCGA	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.1944
p.S169T	DO29890	OV	ICGC	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.1944
p.V171M	TCGA-75-5126	LUAD	TCGA	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.25
p.V171M	DO23711	LUAD	ICGC	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.25
p.S169F	TCGA-BS-A0UV	UCEC	TCGA	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.1944
p.S169F	DO42793	UCEC	ICGC	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.1944
p.S178F	TCGA-D3-A8GC	SKCM	TCGA	DFYSSLP	CBL_PTK	174:180	Mutation altering degron motif	0.6871
p.S178F	TCGA-Q1-A73P	CESC	TCGA	DFYSSLP	CBL_PTK	174:180	Mutation altering degron motif	0.6871
p.S178F	DO49983	CESC	ICGC	DFYSSLP	CBL_PTK	174:180	Mutation altering degron motif	0.6871
p.S178F	DO219878	SKCA	ICGC	DFYSSLP	CBL_PTK	174:180	Mutation altering degron motif	0.6871
p.S178F	DO50281	SKCM	ICGC	DFYSSLP	CBL_PTK	174:180	Mutation altering degron motif	0.6871
p.P180S	TCGA-EE-A29L	SKCM	TCGA	DFYSSLP	CBL_PTK	174:180	Mutation altering degron motif	0.6752
p.P180S	DO222599	MELA	ICGC	DFYSSLP	CBL_PTK	174:180	Mutation altering degron motif	0.6752
p.P180S	DO37835	SKCM	ICGC	DFYSSLP	CBL_PTK	174:180	Mutation altering degron motif	0.6752
p.P186S	TCGA-P6-A5OG	ACC	TCGA	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.1667
p.S173T	DO48451	BLCA	ICGC	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.3056
p.S177I	DO229022	LICA	ICGC	DFYSSLP	CBL_PTK	174:180	Mutation altering degron motif	0.7341
p.S177I	ACH-001302	Neuroblastoma	CCLE	DFYSSLP	CBL_PTK	174:180	Mutation altering degron motif	0.7341
p.P165S	DO222875	MELA	ICGC	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.0833
p.D174G	DO46538	OV	ICGC	DFYSSLP	CBL_PTK	174:180	Mutation altering degron motif	0.7198
p.S169Y	SIDM00193	Colorectal Carcinoma	GDSC	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.1944
p.S169Y	ACH-000991	Colon/Colorectal Cancer	CCLE	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.1944
p.S169Y	SNU-81	large intestine	COSMIC	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.1944
p.A167D	SIDM00965	Small Cell Lung Carcinoma	GDSC	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.1389
p.A167D	SIDM01611	Endometrial Carcinoma	GDSC	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.1389
p.A167D	ACH-000800	Lung Cancer	CCLE	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.1389
p.A167D	ACH-000996	Endometrial/Uterine Cancer	CCLE	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.1389
p.A167D	NCI-H446	lung	COSMIC	DFYSSLP	CBL_PTK	174:180	Mutation rewiring degron network	0.1389

Kaplan plot for ARGFX in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARGFX

UniProt ID: A6NJG6

Entrez ID: 503582

Protein name: Arginine-fifty homeobox

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARGFX in