DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DFYSSLP
Uniprot ID:
A6NJG6
Source protein:
Arginine-fifty homeobox
Source gene:
ARGFX
Class:
CBL_PTK
Location:
174:180
E3 ligase:
CBL
DEGRON score:
0.6633
ASA_SCORE:
40.5714
COIL:
0.9007
CONS_SCORE:
0.5495
DSS_SCORE:
0.3557
HELIX:
0.0421
FCONS_SCORE:
0.9965
RIG_SCORE:
0.7373
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S169T
TCGA-13-2059
OV
TCGA
DFYSSLP
CBL_PTK
0.1944
p.S169T
DO29890
OV
ICGC
DFYSSLP
CBL_PTK
0.1944
p.V171M
TCGA-75-5126
LUAD
TCGA
DFYSSLP
CBL_PTK
0.25
p.V171M
DO23711
LUAD
ICGC
DFYSSLP
CBL_PTK
0.25
p.S169F
TCGA-BS-A0UV
UCEC
TCGA
DFYSSLP
CBL_PTK
0.1944
p.S169F
DO42793
UCEC
ICGC
DFYSSLP
CBL_PTK
0.1944
p.S178F
TCGA-D3-A8GC
SKCM
TCGA
DFYSSLP
CBL_PTK
0.6871
p.S178F
TCGA-Q1-A73P
CESC
TCGA
DFYSSLP
CBL_PTK
0.6871
p.S178F
DO49983
CESC
ICGC
DFYSSLP
CBL_PTK
0.6871
p.S178F
DO219878
SKCA
ICGC
DFYSSLP
CBL_PTK
0.6871
p.S178F
DO50281
SKCM
ICGC
DFYSSLP
CBL_PTK
0.6871
p.P180S
TCGA-EE-A29L
SKCM
TCGA
DFYSSLP
CBL_PTK
0.6752
p.P180S
DO222599
MELA
ICGC
DFYSSLP
CBL_PTK
0.6752
p.P180S
DO37835
SKCM
ICGC
DFYSSLP
CBL_PTK
0.6752
p.P186S
TCGA-P6-A5OG
ACC
TCGA
DFYSSLP
CBL_PTK
0.1667
p.S173T
DO48451
BLCA
ICGC
DFYSSLP
CBL_PTK
0.3056
p.S177I
DO229022
LICA
ICGC
DFYSSLP
CBL_PTK
0.7341
p.S177I
ACH-001302
Neuroblastoma
CCLE
DFYSSLP
CBL_PTK
0.7341
p.P165S
DO222875
MELA
ICGC
DFYSSLP
CBL_PTK
0.0833
p.D174G
DO46538
OV
ICGC
DFYSSLP
CBL_PTK
0.7198
p.S169Y
SIDM00193
Colorectal Carcinoma
GDSC
DFYSSLP
CBL_PTK
0.1944
p.S169Y
ACH-000991
Colon/Colorectal Cancer
CCLE
DFYSSLP
CBL_PTK
0.1944
p.S169Y
SNU-81
large_intestine
COSMIC
DFYSSLP
CBL_PTK
0.1944
p.A167D
SIDM00965
Small Cell Lung Carcinoma
GDSC
DFYSSLP
CBL_PTK
0.1389
p.A167D
SIDM01611
Endometrial Carcinoma
GDSC
DFYSSLP
CBL_PTK
0.1389
p.A167D
ACH-000800
Lung Cancer
CCLE
DFYSSLP
CBL_PTK
0.1389
p.A167D
ACH-000996
Endometrial/Uterine Cancer
CCLE
DFYSSLP
CBL_PTK
0.1389
p.A167D
NCI-H446
lung
COSMIC
DFYSSLP
CBL_PTK
0.1389
Drug responses associated with ARGFX mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DFYSSLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NJG6
Arginine-fifty homeobox
CBL_PTK
174:180
DFYSSLP
CBL
0.6633
More...