DegronMD - A6NKF2(ARID3C)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V324M	TCGA-17-Z015	LUAD	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation altering degron motif	0.6097
p.A305T	TCGA-A5-A0G1	UCEC	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.1111
p.A305T	TCGA-BG-A222	UCEC	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.1111
p.A305T	DO42977	UCEC	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.1111
p.A305T	DO42472	UCEC	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.1111
p.E311D	TCGA-B5-A0JY	UCEC	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.2778
p.E311D	DO8264	COAD	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.2778
p.E311D	DO43041	UCEC	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.2778
p.G327R	TCGA-B6-A0IJ	BRCA	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.3056
p.G327R	DO2813	BRCA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.3056
p.V324L	TCGA-DD-A4NF	LIHC	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation altering degron motif	0.5654
p.V324L	DO44950	LIHC	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation altering degron motif	0.5654
p.K312T	TCGA-DK-A6AW	BLCA	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.3056
p.K312T	DO48566	BLCA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.3056
p.E320K	TCGA-EE-A3AB	SKCM	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation altering degron motif	0.591
p.E320K	DO222670	MELA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation altering degron motif	0.591
p.E320K	DO38057	SKCM	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation altering degron motif	0.591
p.R333Q	TCGA-EI-6917	READ	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.1389
p.R333Q	DO36881	READ	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.1389
p.P331S	TCGA-YD-A9TA	SKCM	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.1944
p.P331S	DO219503	SKCM	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.1944
p.C335G	DO230334	COCA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.0833
p.C335G	DO229010	COCA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.0833
p.C335G	DO229013	COCA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.0833
p.C335G	DO229016	COCA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.0833
p.C335G	DO229003	COCA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.0833
p.C335G	DO229346	LAML	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.0833
p.C335G	DO229489	LAML	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.0833
p.C335G	DO230659	LAML	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.0833
p.C335G	DO231140	LAML	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.0833
p.C335G	DO228947	LICA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.0833
p.M336T	DO231977	LICA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.0556
p.R310W	DO231583	LINC	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.25
p.M336V	DO233292	NACA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation rewiring degron network	0.0556
p.E316K	SIDM00789	Colorectal Carcinoma	GDSC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation altering degron motif	0.591
p.E316K	ACH-000997	Colon/Colorectal Cancer	CCLE	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation altering degron motif	0.591
p.E316K	HCT-15	large intestine	COSMIC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation altering degron motif	0.591
p.E316Q	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation altering degron motif	0.5633
p.E316Q	ACH-000878	Lung Cancer	CCLE	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation altering degron motif	0.5633
p.E316Q	HCC-15	lung	COSMIC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation altering degron motif	0.5633
p.A323P	SIDM01753	Gastric Carcinoma	GDSC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation altering degron motif	0.6392
p.A323P	ACH-000239	Gastric Cancer	CCLE	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	313:326	Mutation altering degron motif	0.6392

Kaplan plot for ARID3C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARID3C

UniProt ID: A6NKF2

Entrez ID: 138715

Protein name: AT-rich interactive domain-containing protein 3C (ARID domain-containing protein 3C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARID3C in