DegronMD

Uniprot ID: A6NKF2

Source protein: AT-rich interactive domain-containing protein 3C

Source gene: ARID3C

Class: DEG_ODPH_VHL_1

Location: 313:326

E3 ligase: VHL

DEGRON score: 0.9974

ASA_SCORE: 100.6786

COIL: 0.8119

CONS_SCORE: 0.4806

DSS_SCORE: 0.6471

HELIX: 0.1804

FCONS_SCORE: 1.1225

RIG_SCORE: 0.664

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V324M	TCGA-17-Z015	LUAD	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.6097
p.A305T	TCGA-A5-A0G1	UCEC	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.1111
p.A305T	TCGA-BG-A222	UCEC	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.1111
p.A305T	DO42977	UCEC	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.1111
p.A305T	DO42472	UCEC	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.1111
p.E311D	TCGA-B5-A0JY	UCEC	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.2778
p.E311D	DO8264	COAD	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.2778
p.E311D	DO43041	UCEC	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.2778
p.G327R	TCGA-B6-A0IJ	BRCA	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.3056
p.G327R	DO2813	BRCA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.3056
p.V324L	TCGA-DD-A4NF	LIHC	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.5654
p.V324L	DO44950	LIHC	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.5654
p.K312T	TCGA-DK-A6AW	BLCA	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.3056
p.K312T	DO48566	BLCA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.3056
p.E320K	TCGA-EE-A3AB	SKCM	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.591
p.E320K	DO222670	MELA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.591
p.E320K	DO38057	SKCM	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.591
p.R333Q	TCGA-EI-6917	READ	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.1389
p.R333Q	DO36881	READ	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.1389
p.P331S	TCGA-YD-A9TA	SKCM	TCGA	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.1944
p.P331S	DO219503	SKCM	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.1944
p.C335G	DO230334	COCA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.0833
p.C335G	DO229010	COCA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.0833
p.C335G	DO229013	COCA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.0833
p.C335G	DO229016	COCA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.0833
p.C335G	DO229003	COCA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.0833
p.C335G	DO229346	LAML	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.0833
p.C335G	DO229489	LAML	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.0833
p.C335G	DO230659	LAML	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.0833
p.C335G	DO231140	LAML	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.0833
p.C335G	DO228947	LICA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.0833
p.M336T	DO231977	LICA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.0556
p.R310W	DO231583	LINC	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.25
p.M336V	DO233292	NACA	ICGC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.0556
p.E316K	SIDM00789	Colorectal Carcinoma	GDSC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.591
p.E316K	ACH-000997	Colon/Colorectal Cancer	CCLE	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.591
p.E316K	HCT-15	large_intestine	COSMIC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.591
p.E316Q	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.5633
p.E316Q	ACH-000878	Lung Cancer	CCLE	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.5633
p.E316Q	HCC-15	lung	COSMIC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.5633
p.A323P	SIDM01753	Gastric Carcinoma	GDSC	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.6392
p.A323P	ACH-000239	Gastric Cancer	CCLE	LAPEEPPEKRAVLM	DEG_ODPH_VHL_1	0.6392

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPEEPPEKRAVLM

Degron related mutations and impact score

Drug responses associated with ARID3C mutations

All proteins holding degron of LAPEEPPEKRAVLM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKF2	AT-rich interactive domain-containing protein 3C	DEG_ODPH_VHL_1	313:326	LAPEEPPEKRAVLM	VHL	0.9974	More...