DegronMD - A6NLU5(VSTM2B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R128H	TCGA-A6-6781	COAD	TCGA	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.0556
p.R128H	DO8447	COAD	ICGC	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.0556
p.R113Q	TCGA-AA-A022	COAD	TCGA	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation altering degron motif	0.6218
p.R113Q	DO10647	COAD	ICGC	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation altering degron motif	0.6218
p.R128C	TCGA-EA-A439	CESC	TCGA	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.0556
p.R128C	DO44297	CESC	ICGC	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.0556
p.G123A	DO233153	GACA	ICGC	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.1944
p.R128L	DO228948	LICA	ICGC	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.0556
p.R128L	DO229025	LICA	ICGC	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.0556
p.V117L	DO229032	LICA	ICGC	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation altering degron motif	0.5654
p.R113W	DO33004	PACA	ICGC	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation altering degron motif	0.7523
p.R113W	SIDM00489	Oral Cavity Carcinoma	GDSC	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation altering degron motif	0.7523
p.R113W	ACH-002043	Head and Neck Cancer	CCLE	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation altering degron motif	0.7523
p.R113W	Ca9-22	upper aerodigestive tract	COSMIC	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation altering degron motif	0.7523
p.E122V	SIDM01638	Non-Cancerous	GDSC	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.2222
p.E122V	SIDM00172	Head and Neck Carcinoma	GDSC	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.2222
p.V124M	SIDM00447	B-Lymphoblastic Leukemia	GDSC	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.1667
p.V124M	ACH-000960	Leukemia	CCLE	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.1667
p.V124M	REH	haematopoietic and lymphoid tissue	COSMIC	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.1667
p.V124L	ACH-001863	Bile Duct Cancer	CCLE	HRLRLSAVR	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VSTM2B

UniProt ID: A6NLU5

Entrez ID: 342865

Protein name: V-set and transmembrane domain-containing protein 2B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VSTM2B in