DegronMD

Uniprot ID: A6NLU5

Source protein: V-set and transmembrane domain-containing protein 2B

Source gene: VSTM2B

Class: DEG_APCC_DBOX_1

Location: 110:118

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6648

ASA_SCORE: 57.6667

COIL: 0.3941

CONS_SCORE: 0.8851

DSS_SCORE: 0.3104

HELIX: 0.0297

FCONS_SCORE: 0.937

RIG_SCORE: 0.8206

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R128H	TCGA-A6-6781	COAD	TCGA	HRLRLSAVR	DEG_APCC_DBOX_1	0.0556
p.R128H	DO8447	COAD	ICGC	HRLRLSAVR	DEG_APCC_DBOX_1	0.0556
p.R113Q	TCGA-AA-A022	COAD	TCGA	HRLRLSAVR	DEG_APCC_DBOX_1	0.6218
p.R113Q	DO10647	COAD	ICGC	HRLRLSAVR	DEG_APCC_DBOX_1	0.6218
p.R128C	TCGA-EA-A439	CESC	TCGA	HRLRLSAVR	DEG_APCC_DBOX_1	0.0556
p.R128C	DO44297	CESC	ICGC	HRLRLSAVR	DEG_APCC_DBOX_1	0.0556
p.G123A	DO233153	GACA	ICGC	HRLRLSAVR	DEG_APCC_DBOX_1	0.1944
p.R128L	DO228948	LICA	ICGC	HRLRLSAVR	DEG_APCC_DBOX_1	0.0556
p.R128L	DO229025	LICA	ICGC	HRLRLSAVR	DEG_APCC_DBOX_1	0.0556
p.V117L	DO229032	LICA	ICGC	HRLRLSAVR	DEG_APCC_DBOX_1	0.5654
p.R113W	DO33004	PACA	ICGC	HRLRLSAVR	DEG_APCC_DBOX_1	0.7523
p.R113W	SIDM00489	Oral Cavity Carcinoma	GDSC	HRLRLSAVR	DEG_APCC_DBOX_1	0.7523
p.R113W	ACH-002043	Head and Neck Cancer	CCLE	HRLRLSAVR	DEG_APCC_DBOX_1	0.7523
p.R113W	Ca9-22	upper_aerodigestive_tract	COSMIC	HRLRLSAVR	DEG_APCC_DBOX_1	0.7523
p.E122V	SIDM01638	Non-Cancerous	GDSC	HRLRLSAVR	DEG_APCC_DBOX_1	0.2222
p.E122V	SIDM00172	Head and Neck Carcinoma	GDSC	HRLRLSAVR	DEG_APCC_DBOX_1	0.2222
p.V124M	SIDM00447	B-Lymphoblastic Leukemia	GDSC	HRLRLSAVR	DEG_APCC_DBOX_1	0.1667
p.V124M	ACH-000960	Leukemia	CCLE	HRLRLSAVR	DEG_APCC_DBOX_1	0.1667
p.V124M	REH	haematopoietic_and_lymphoid_tissue	COSMIC	HRLRLSAVR	DEG_APCC_DBOX_1	0.1667
p.V124L	ACH-001863	Bile Duct Cancer	CCLE	HRLRLSAVR	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NLU5	V-set and transmembrane domain-containing protein 2B	DEG_APCC_DBOX_1	110:118	HRLRLSAVR	APC,CDC20,FZR1	0.6648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons