DegronMD - A6NP61(ZAR1L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P128T	TCGA-IR-A3LH	CESC	TCGA	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.0556
p.P128T	DO44381	CESC	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.0556
p.P128T	DO234374	ESAD	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.0556
p.A136T	TCGA-SJ-A6ZI	UCEC	TCGA	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.2778
p.A136T	DO222946	BTCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.2778
p.A136T	DO227976	COCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.2778
p.A136T	DO219784	UCEC	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.2778
p.A136T	ACH-000974	Endometrial/Uterine Cancer	CCLE	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.2778
p.A136T	ACH-002026	Endometrial/Uterine Cancer	CCLE	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.2778
p.R144C	DO225056	BRCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.719
p.T137A	DO230334	COCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation blocking phosphorylation signal	0.75
p.T137A	DO229010	COCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation blocking phosphorylation signal	0.75
p.T137A	DO229013	COCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation blocking phosphorylation signal	0.75
p.T137A	DO229016	COCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation blocking phosphorylation signal	0.75
p.T137A	DO229003	COCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation blocking phosphorylation signal	0.75
p.T137A	DO229005	COCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation blocking phosphorylation signal	0.75
p.T137A	DO229346	LAML	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation blocking phosphorylation signal	0.75
p.T137A	DO228941	LICA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation blocking phosphorylation signal	0.75
p.T137A	DO228947	LICA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation blocking phosphorylation signal	0.75
p.T137A	DO230937	LUSC	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation blocking phosphorylation signal	0.75
p.R144H	DO223019	ESCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.7133
p.L142F	DO223022	ESCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.6981
p.AE152AK	DO222843	MELA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0
p.R139H	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.8244
p.R146W	SIDM00487	Colorectal Carcinoma	GDSC	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.7523
p.R146W	ACH-000963	Colon/Colorectal Cancer	CCLE	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.7523
p.P128Q	ACH-000869	Lung Cancer	CCLE	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.0556
p.A152V	ACH-001515	Cervical Cancer	CCLE	GRRGLIRLR	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZAR1L

UniProt ID: A6NP61

Entrez ID: 646799

Protein name: ZAR1-like protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZAR1L in