DegronMD

Uniprot ID: A6NP61

Source protein: ZAR1-like protein

Source gene: ZAR1L

Class: DEG_APCC_DBOX_1

Location: 138:146

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9222

ASA_SCORE: 87.3333

COIL: 0.7039

CONS_SCORE: 0.2701

DSS_SCORE: 0.6311

HELIX: 0.049

FCONS_SCORE: 1.2081

RIG_SCORE: 0.7204

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P128T	TCGA-IR-A3LH	CESC	TCGA	GRRGLIRLR	DEG_APCC_DBOX_1	0.0556
p.P128T	DO44381	CESC	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.0556
p.P128T	DO234374	ESAD	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.0556
p.A136T	TCGA-SJ-A6ZI	UCEC	TCGA	GRRGLIRLR	DEG_APCC_DBOX_1	0.2778
p.A136T	DO222946	BTCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.2778
p.A136T	DO227976	COCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.2778
p.A136T	DO219784	UCEC	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.2778
p.A136T	ACH-000974	Endometrial/Uterine Cancer	CCLE	GRRGLIRLR	DEG_APCC_DBOX_1	0.2778
p.A136T	ACH-002026	Endometrial/Uterine Cancer	CCLE	GRRGLIRLR	DEG_APCC_DBOX_1	0.2778
p.R144C	DO225056	BRCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.719
p.T137A	DO230334	COCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.75
p.T137A	DO229010	COCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.75
p.T137A	DO229013	COCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.75
p.T137A	DO229016	COCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.75
p.T137A	DO229003	COCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.75
p.T137A	DO229005	COCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.75
p.T137A	DO229346	LAML	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.75
p.T137A	DO228941	LICA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.75
p.T137A	DO228947	LICA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.75
p.T137A	DO230937	LUSC	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.75
p.R144H	DO223019	ESCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.7133
p.L142F	DO223022	ESCA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0.6981
p.AE152AK	DO222843	MELA	ICGC	GRRGLIRLR	DEG_APCC_DBOX_1	0
p.R139H	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	GRRGLIRLR	DEG_APCC_DBOX_1	0.8244
p.R146W	SIDM00487	Colorectal Carcinoma	GDSC	GRRGLIRLR	DEG_APCC_DBOX_1	0.7523
p.R146W	ACH-000963	Colon/Colorectal Cancer	CCLE	GRRGLIRLR	DEG_APCC_DBOX_1	0.7523
p.P128Q	ACH-000869	Lung Cancer	CCLE	GRRGLIRLR	DEG_APCC_DBOX_1	0.0556
p.A152V	ACH-001515	Cervical Cancer	CCLE	GRRGLIRLR	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRRGLIRLR

Degron related mutations and impact score

Drug responses associated with ZAR1L mutations

All proteins holding degron of GRRGLIRLR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NP61	ZAR1-like protein	DEG_APCC_DBOX_1	138:146	GRRGLIRLR	APC,CDC20,FZR1	0.9222	More...