DegronMD - A7MCY6(TBKBP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R228W	TCGA-DK-A6AW	BLCA	TCGA	PGSTPSVS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.1667
p.R228W	DO48566	BLCA	ICGC	PGSTPSVS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.1667
p.R228Q	TCGA-EB-A3XB	SKCM	TCGA	PGSTPSVS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.1667
p.R228Q	DO37856	SKCM	ICGC	PGSTPSVS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.1667
p.R228Q	SIDM00217	Colorectal Carcinoma	GDSC	PGSTPSVS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.1667
p.R228Q	SNU-1040	large intestine	COSMIC	PGSTPSVS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.1667
p.R227L	DO229045	LICA	ICGC	PGSTPSVS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.1944
p.G206V	DO48672	LIRI	ICGC	PGSTPSVS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.0833
p.V221A	SIDM00217	Colorectal Carcinoma	GDSC	PGSTPSVS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.5825
p.V221A	ACH-000999	Colon/Colorectal Cancer	CCLE	PGSTPSVS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.5825
p.V221A	SNU-1040	large intestine	COSMIC	PGSTPSVS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.5825
p.G213D	ACH-002005	Skin Cancer	CCLE	PGSTPSVS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.2778
p.R205Q	769-P	kidney	COSMIC	PGSTPSVS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.0556
p.R205Q	SNU-175	large intestine	COSMIC	PGSTPSVS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.0556
p.R219Q	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PGSTPSVS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7329
p.Q208R	IM-95	stomach	COSMIC	PGSTPSVS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.1389

Kaplan plot for TBKBP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TBKBP1

UniProt ID: A7MCY6

Entrez ID: 9755

Protein name: TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TBKBP1 in