DegronMD

Uniprot ID: A7MCY6

Source protein: TANK-binding kinase 1-binding protein 1

Source gene: TBKBP1

Class: DEG_SCF_FBW7_1

Location: 215:222

E3 ligase: FBXW7

DEGRON score: 0.93

ASA_SCORE: 66.5125

COIL: 0.8424

CONS_SCORE: 0.5685

DSS_SCORE: 0.5271

HELIX: 0.1121

FCONS_SCORE: 0.8791

RIG_SCORE: 0.6392

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R228W	TCGA-DK-A6AW	BLCA	TCGA	PGSTPSVS	DEG_SCF_FBW7_1	0.1667
p.R228W	DO48566	BLCA	ICGC	PGSTPSVS	DEG_SCF_FBW7_1	0.1667
p.R228Q	TCGA-EB-A3XB	SKCM	TCGA	PGSTPSVS	DEG_SCF_FBW7_1	0.1667
p.R228Q	DO37856	SKCM	ICGC	PGSTPSVS	DEG_SCF_FBW7_1	0.1667
p.R228Q	SIDM00217	Colorectal Carcinoma	GDSC	PGSTPSVS	DEG_SCF_FBW7_1	0.1667
p.R228Q	SNU-1040	large_intestine	COSMIC	PGSTPSVS	DEG_SCF_FBW7_1	0.1667
p.R227L	DO229045	LICA	ICGC	PGSTPSVS	DEG_SCF_FBW7_1	0.1944
p.G206V	DO48672	LIRI	ICGC	PGSTPSVS	DEG_SCF_FBW7_1	0.0833
p.V221A	SIDM00217	Colorectal Carcinoma	GDSC	PGSTPSVS	DEG_SCF_FBW7_1	0.5825
p.V221A	ACH-000999	Colon/Colorectal Cancer	CCLE	PGSTPSVS	DEG_SCF_FBW7_1	0.5825
p.V221A	SNU-1040	large_intestine	COSMIC	PGSTPSVS	DEG_SCF_FBW7_1	0.5825
p.G213D	ACH-002005	Skin Cancer	CCLE	PGSTPSVS	DEG_SCF_FBW7_1	0.2778
p.R205Q	769-P	kidney	COSMIC	PGSTPSVS	DEG_SCF_FBW7_1	0.0556
p.R205Q	SNU-175	large_intestine	COSMIC	PGSTPSVS	DEG_SCF_FBW7_1	0.0556
p.R219Q	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTPSVS	DEG_SCF_FBW7_1	0.7329
p.Q208R	IM-95	stomach	COSMIC	PGSTPSVS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7MCY6	TANK-binding kinase 1-binding protein 1	DEG_SCF_FBW7_1	215:222	PGSTPSVS	FBXW7	0.93	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons