DegronMD - A8K7I4(CLCA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I866T	TCGA-A5-A0G2	UCEC	TCGA	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.3056
p.I866T	DO41235	UCEC	ICGC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.3056
p.T880M	TCGA-A5-A1OF	UCEC	TCGA	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.1667
p.T880M	DO42568	UCEC	ICGC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.1667
p.T880M	SIDM01090	Colorectal Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.1667
p.N858K	TCGA-CC-A8HV	LIHC	TCGA	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.0833
p.N858K	DO52189	LIHC	ICGC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.0833
p.I859V	TCGA-CC-A8HV	LIHC	TCGA	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.1111
p.I859V	DO52189	LIHC	ICGC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.1111
p.P877S	TCGA-DU-6392	LGG	TCGA	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.25
p.P877S	DO22237	LGG	ICGC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.25
p.A860V	TCGA-FI-A2D5	UCEC	TCGA	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.1389
p.A860V	DO41331	UCEC	ICGC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.1389
p.P871L	DO228483	BRCA	ICGC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	DO229010	COCA	ICGC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM00586	Hepatocellular Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM00578	Neuroblastoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM01151	Hepatocellular Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM01005	Acute Myeloid Leukemia	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM00457	Plasma Cell Myeloma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM00040	Gastric Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM00238	Ovarian Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM00988	Kidney Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM00274	Gastric Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM01569	Hepatocellular Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM01735	Biliary Tract Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM01660	Kidney Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM01444	Glioblastoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM01779	Gastric Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM00163	Biliary Tract Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM00959	Acute Myeloid Leukemia	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.P871L	SIDM00164	Biliary Tract Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation altering degron motif	0.7582
p.E879D	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.1944
p.E879D	ACH-000726	Esophageal Cancer	CCLE	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.1944
p.S876I	ACH-000975	Lung Cancer	CCLE	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.2778
p.P877A	ACH-001408	Bladder Cancer	CCLE	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.25
p.C884F	ACH-001853	Bile Duct Cancer	CCLE	PPQTPPET	DEG_SCF_FBW7_1	867:874	Mutation rewiring degron network	0.0556

Kaplan plot for CLCA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLCA1

UniProt ID: A8K7I4

Entrez ID: 1179

Protein name: Calcium-activated chloride channel regulator 1 (EC 3.4.-.-) (Calcium-activated chloride channel family member 1) (hCLCA1) (Calcium-activated chloride channel protein 1) (CaCC-1) (hCaCC-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLCA1 in