DegronMD

Uniprot ID: A8K7I4

Source protein: Calcium-activated chloride channel regulator 1

Source gene: CLCA1

Class: DEG_SCF_FBW7_1

Location: 867:874

E3 ligase: FBXW7

DEGRON score: 0.706

ASA_SCORE: 91.45

COIL: 0.9573

CONS_SCORE: 0.4104

DSS_SCORE: 0.6155

HELIX: 0.0071

FCONS_SCORE: 1.0162

RIG_SCORE: 0.6031

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I866T	TCGA-A5-A0G2	UCEC	TCGA	PPQTPPET	DEG_SCF_FBW7_1	0.3056
p.I866T	DO41235	UCEC	ICGC	PPQTPPET	DEG_SCF_FBW7_1	0.3056
p.T880M	TCGA-A5-A1OF	UCEC	TCGA	PPQTPPET	DEG_SCF_FBW7_1	0.1667
p.T880M	DO42568	UCEC	ICGC	PPQTPPET	DEG_SCF_FBW7_1	0.1667
p.T880M	SIDM01090	Colorectal Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.1667
p.N858K	TCGA-CC-A8HV	LIHC	TCGA	PPQTPPET	DEG_SCF_FBW7_1	0.0833
p.N858K	DO52189	LIHC	ICGC	PPQTPPET	DEG_SCF_FBW7_1	0.0833
p.I859V	TCGA-CC-A8HV	LIHC	TCGA	PPQTPPET	DEG_SCF_FBW7_1	0.1111
p.I859V	DO52189	LIHC	ICGC	PPQTPPET	DEG_SCF_FBW7_1	0.1111
p.P877S	TCGA-DU-6392	LGG	TCGA	PPQTPPET	DEG_SCF_FBW7_1	0.25
p.P877S	DO22237	LGG	ICGC	PPQTPPET	DEG_SCF_FBW7_1	0.25
p.A860V	TCGA-FI-A2D5	UCEC	TCGA	PPQTPPET	DEG_SCF_FBW7_1	0.1389
p.A860V	DO41331	UCEC	ICGC	PPQTPPET	DEG_SCF_FBW7_1	0.1389
p.P871L	DO228483	BRCA	ICGC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	DO229010	COCA	ICGC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM00586	Hepatocellular Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM00578	Neuroblastoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM01151	Hepatocellular Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM01005	Acute Myeloid Leukemia	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM00457	Plasma Cell Myeloma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM00040	Gastric Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM00238	Ovarian Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM00988	Kidney Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM00274	Gastric Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM01569	Hepatocellular Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM01735	Biliary Tract Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM01660	Kidney Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM01444	Glioblastoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM01779	Gastric Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM00163	Biliary Tract Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM00959	Acute Myeloid Leukemia	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.P871L	SIDM00164	Biliary Tract Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.7582
p.E879D	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	PPQTPPET	DEG_SCF_FBW7_1	0.1944
p.E879D	ACH-000726	Esophageal Cancer	CCLE	PPQTPPET	DEG_SCF_FBW7_1	0.1944
p.S876I	ACH-000975	Lung Cancer	CCLE	PPQTPPET	DEG_SCF_FBW7_1	0.2778
p.P877A	ACH-001408	Bladder Cancer	CCLE	PPQTPPET	DEG_SCF_FBW7_1	0.25
p.C884F	ACH-001853	Bile Duct Cancer	CCLE	PPQTPPET	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPQTPPET

Degron related mutations and impact score

Drug responses associated with CLCA1 mutations

All proteins holding degron of PPQTPPET

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8K7I4	Calcium-activated chloride channel regulator 1	DEG_SCF_FBW7_1	867:874	PPQTPPET	FBXW7	0.706	More...