DegronMD - A8MPS7(YDJC)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P316T	DO229027	LICA	ICGC	LEPFLE	LIG_APCC_ABBA_1	314:319	Mutation altering degron motif	0.7031
p.L323H	SIDM01293	Colorectal Carcinoma	GDSC	LEPFLE	LIG_APCC_ABBA_1	314:319	Mutation rewiring degron network	0.2222
p.L318Q	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LEPFLE	LIG_APCC_ABBA_1	314:319	Mutation altering degron motif	0.6654
p.L318Q	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	LEPFLE	LIG_APCC_ABBA_1	314:319	Mutation altering degron motif	0.6654
p.L318Q	Farage	haematopoietic and lymphoid tissue	COSMIC	LEPFLE	LIG_APCC_ABBA_1	314:319	Mutation altering degron motif	0.6654
p.L318Q	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LEPFLE	LIG_APCC_ABBA_1	314:319	Mutation altering degron motif	0.6654
p.E307G	SIDM01664	Prostate Carcinoma	GDSC	LEPFLE	LIG_APCC_ABBA_1	314:319	Mutation rewiring degron network	0.1389
p.E307G	ACH-000952	Prostate Cancer	CCLE	LEPFLE	LIG_APCC_ABBA_1	314:319	Mutation rewiring degron network	0.1389
p.P316L	SIDM01662	Plasma Cell Myeloma	GDSC	LEPFLE	LIG_APCC_ABBA_1	314:319	Mutation altering degron motif	0.6471
p.P316L	ACH-000564	Myeloma	CCLE	LEPFLE	LIG_APCC_ABBA_1	314:319	Mutation altering degron motif	0.6471

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons