DegronMD

Uniprot ID: A8MPS7

Source protein: Carbohydrate deacetylase

Source gene: YDJC

Class: LIG_APCC_ABBA_1

Location: 314:319

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9127

ASA_SCORE: 103.85

COIL: 0.9015

CONS_SCORE: 0.3231

DSS_SCORE: 0.6634

HELIX: 0.048

FCONS_SCORE: 0.978

RIG_SCORE: 0.7792

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P316T	DO229027	LICA	ICGC	LEPFLE	LIG_APCC_ABBA_1	0.7031
p.L323H	SIDM01293	Colorectal Carcinoma	GDSC	LEPFLE	LIG_APCC_ABBA_1	0.2222
p.L318Q	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LEPFLE	LIG_APCC_ABBA_1	0.6654
p.L318Q	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	LEPFLE	LIG_APCC_ABBA_1	0.6654
p.L318Q	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	LEPFLE	LIG_APCC_ABBA_1	0.6654
p.L318Q	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LEPFLE	LIG_APCC_ABBA_1	0.6654
p.E307G	SIDM01664	Prostate Carcinoma	GDSC	LEPFLE	LIG_APCC_ABBA_1	0.1389
p.E307G	ACH-000952	Prostate Cancer	CCLE	LEPFLE	LIG_APCC_ABBA_1	0.1389
p.P316L	SIDM01662	Plasma Cell Myeloma	GDSC	LEPFLE	LIG_APCC_ABBA_1	0.6471
p.P316L	ACH-000564	Myeloma	CCLE	LEPFLE	LIG_APCC_ABBA_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MPS7	Carbohydrate deacetylase	LIG_APCC_ABBA_1	314:319	LEPFLE	APC,CDC20,FZR1	0.9127	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons