DegronMD - A8MTA8(FAM166B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R65Q	TCGA-A5-A0G2	UCEC	TCGA	HRTLLPPIR	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.6218
p.R65Q	DO41235	UCEC	ICGC	HRTLLPPIR	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.6218
p.R74M	TCGA-BS-A0UF	UCEC	TCGA	HRTLLPPIR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.0833
p.R74M	DO41488	UCEC	ICGC	HRTLLPPIR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.0833
p.R68I	TCGA-EO-A22U	UCEC	TCGA	HRTLLPPIR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.25
p.R68I	DO43755	UCEC	ICGC	HRTLLPPIR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.25
p.P62L	TCGA-G3-A5SK	LIHC	TCGA	HRTLLPPIR	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.6471
p.P62L	DO45005	LIHC	ICGC	HRTLLPPIR	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.6471
p.P55T	TCGA-L5-A8NM	ESCA	TCGA	HRTLLPPIR	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.2778
p.P63L	SIDM02020	Esophageal Carcinoma	GDSC	HRTLLPPIR	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.6471
p.R58C	SIDM00173	Head and Neck Carcinoma	GDSC	HRTLLPPIR	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.8301
p.R58C	SIDM00171	Colorectal Carcinoma	GDSC	HRTLLPPIR	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.8301
p.R58C	SIDM01391	Neuroblastoma	GDSC	HRTLLPPIR	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.8301

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons