DegronMD

Uniprot ID: A8MTA8

Source protein: Protein FAM166B

Source gene: FAM166B

Class: DEG_APCC_DBOX_1

Location: 57:65

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8731

ASA_SCORE: 101.6556

COIL: 0.873

CONS_SCORE: 0.4478

DSS_SCORE: 0.5243

HELIX: 0.0303

FCONS_SCORE: 1.1667

RIG_SCORE: 0.7002

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R65Q	TCGA-A5-A0G2	UCEC	TCGA	HRTLLPPIR	DEG_APCC_DBOX_1	0.6218
p.R65Q	DO41235	UCEC	ICGC	HRTLLPPIR	DEG_APCC_DBOX_1	0.6218
p.R74M	TCGA-BS-A0UF	UCEC	TCGA	HRTLLPPIR	DEG_APCC_DBOX_1	0.0833
p.R74M	DO41488	UCEC	ICGC	HRTLLPPIR	DEG_APCC_DBOX_1	0.0833
p.R68I	TCGA-EO-A22U	UCEC	TCGA	HRTLLPPIR	DEG_APCC_DBOX_1	0.25
p.R68I	DO43755	UCEC	ICGC	HRTLLPPIR	DEG_APCC_DBOX_1	0.25
p.P62L	TCGA-G3-A5SK	LIHC	TCGA	HRTLLPPIR	DEG_APCC_DBOX_1	0.6471
p.P62L	DO45005	LIHC	ICGC	HRTLLPPIR	DEG_APCC_DBOX_1	0.6471
p.P55T	TCGA-L5-A8NM	ESCA	TCGA	HRTLLPPIR	DEG_APCC_DBOX_1	0.2778
p.P63L	SIDM02020	Esophageal Carcinoma	GDSC	HRTLLPPIR	DEG_APCC_DBOX_1	0.6471
p.R58C	SIDM00173	Head and Neck Carcinoma	GDSC	HRTLLPPIR	DEG_APCC_DBOX_1	0.8301
p.R58C	SIDM00171	Colorectal Carcinoma	GDSC	HRTLLPPIR	DEG_APCC_DBOX_1	0.8301
p.R58C	SIDM01391	Neuroblastoma	GDSC	HRTLLPPIR	DEG_APCC_DBOX_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MTA8	Protein FAM166B	DEG_APCC_DBOX_1	57:65	HRTLLPPIR	APC,CDC20,FZR1	0.8731	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons