DegronMD - A8MV65(VGLL3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G128A	TCGA-63-A5MG	LUSC	TCGA	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0833
p.G128A	DO52019	LUSC	ICGC	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0833
p.A113D	TCGA-86-8279	LUAD	TCGA	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.3056
p.A113D	DO24140	LUAD	ICGC	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.3056
p.L129I	TCGA-A6-3809	COAD	TCGA	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0556
p.L129I	TCGA-DX-A6YS	SARC	TCGA	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0556
p.L129I	DO8722	COAD	ICGC	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0556
p.L129I	DO220005	SARC	ICGC	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0556
p.E104G	TCGA-AX-A05Z	UCEC	TCGA	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0556
p.E104G	DO40884	UCEC	ICGC	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0556
p.R108I	TCGA-EO-A3AY	UCEC	TCGA	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1667
p.R108I	DO43202	UCEC	ICGC	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1667
p.P118S	TCGA-RP-A695	SKCM	TCGA	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.5641
p.P118S	DO51270	SKCM	ICGC	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.5641
p.Q112K	DO229029	LICA	ICGC	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.2778
p.I122S	DO231127	LUSC	ICGC	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.25
p.S123L	DO220873	MELA	ICGC	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.2222
p.S125N	SIDM00118	Colorectal Carcinoma	GDSC	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1667
p.S125N	ACH-001081	Colon/Colorectal Cancer	CCLE	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1667
p.S125N	HCC2998	large intestine	COSMIC	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1667
p.R108T	SIDM00008	Ovarian Carcinoma	GDSC	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1667
p.R108T	ACH-000796	Ovarian Cancer	CCLE	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1667
p.I114N	ACH-000786	Lymphoma	CCLE	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.728
p.I114N	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.728
p.I114N	Daudi	haematopoietic and lymphoid tissue	COSMIC	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.728
p.L116F	Daudi	haematopoietic and lymphoid tissue	COSMIC	ITLHPE	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.6981

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VGLL3

UniProt ID: A8MV65

Entrez ID: 389136

Protein name: Transcription cofactor vestigial-like protein 3 (Vgl-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VGLL3 in