DegronMD

Uniprot ID: A8MV65

Source protein: Transcription cofactor vestigial-like protein 3

Source gene: VGLL3

Class: LIG_APCC_ABBA_1

Location: 114:119

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6789

ASA_SCORE: 92.05

COIL: 0.8843

CONS_SCORE: 0.347

DSS_SCORE: 0.2866

HELIX: 0.079

FCONS_SCORE: 0.5921

RIG_SCORE: 0.7911

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G128A	TCGA-63-A5MG	LUSC	TCGA	ITLHPE	LIG_APCC_ABBA_1	0.0833
p.G128A	DO52019	LUSC	ICGC	ITLHPE	LIG_APCC_ABBA_1	0.0833
p.A113D	TCGA-86-8279	LUAD	TCGA	ITLHPE	LIG_APCC_ABBA_1	0.3056
p.A113D	DO24140	LUAD	ICGC	ITLHPE	LIG_APCC_ABBA_1	0.3056
p.L129I	TCGA-A6-3809	COAD	TCGA	ITLHPE	LIG_APCC_ABBA_1	0.0556
p.L129I	TCGA-DX-A6YS	SARC	TCGA	ITLHPE	LIG_APCC_ABBA_1	0.0556
p.L129I	DO8722	COAD	ICGC	ITLHPE	LIG_APCC_ABBA_1	0.0556
p.L129I	DO220005	SARC	ICGC	ITLHPE	LIG_APCC_ABBA_1	0.0556
p.E104G	TCGA-AX-A05Z	UCEC	TCGA	ITLHPE	LIG_APCC_ABBA_1	0.0556
p.E104G	DO40884	UCEC	ICGC	ITLHPE	LIG_APCC_ABBA_1	0.0556
p.R108I	TCGA-EO-A3AY	UCEC	TCGA	ITLHPE	LIG_APCC_ABBA_1	0.1667
p.R108I	DO43202	UCEC	ICGC	ITLHPE	LIG_APCC_ABBA_1	0.1667
p.P118S	TCGA-RP-A695	SKCM	TCGA	ITLHPE	LIG_APCC_ABBA_1	0.5641
p.P118S	DO51270	SKCM	ICGC	ITLHPE	LIG_APCC_ABBA_1	0.5641
p.Q112K	DO229029	LICA	ICGC	ITLHPE	LIG_APCC_ABBA_1	0.2778
p.I122S	DO231127	LUSC	ICGC	ITLHPE	LIG_APCC_ABBA_1	0.25
p.S123L	DO220873	MELA	ICGC	ITLHPE	LIG_APCC_ABBA_1	0.2222
p.S125N	SIDM00118	Colorectal Carcinoma	GDSC	ITLHPE	LIG_APCC_ABBA_1	0.1667
p.S125N	ACH-001081	Colon/Colorectal Cancer	CCLE	ITLHPE	LIG_APCC_ABBA_1	0.1667
p.S125N	HCC2998	large_intestine	COSMIC	ITLHPE	LIG_APCC_ABBA_1	0.1667
p.R108T	SIDM00008	Ovarian Carcinoma	GDSC	ITLHPE	LIG_APCC_ABBA_1	0.1667
p.R108T	ACH-000796	Ovarian Cancer	CCLE	ITLHPE	LIG_APCC_ABBA_1	0.1667
p.I114N	ACH-000786	Lymphoma	CCLE	ITLHPE	LIG_APCC_ABBA_1	0.728
p.I114N	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	ITLHPE	LIG_APCC_ABBA_1	0.728
p.I114N	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ITLHPE	LIG_APCC_ABBA_1	0.728
p.L116F	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ITLHPE	LIG_APCC_ABBA_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MV65	Transcription cofactor vestigial-like protein 3	LIG_APCC_ABBA_1	114:119	ITLHPE	APC,CDC20,FZR1	0.6789	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITLHPE

Degron related mutations and impact score

Drug responses associated with VGLL3 mutations

All proteins holding degron of ITLHPE