DegronMD - A8MVW5(HEPACAM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T203A	TCGA-BH-A18G	BRCA	TCGA	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation blocking phosphorylation signal	0.5
p.S196F	TCGA-D3-A1Q5	SKCM	TCGA	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.25
p.S196F	TCGA-EE-A2GC	SKCM	TCGA	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.25
p.S196F	DO37839	SKCM	ICGC	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.25
p.S196F	DO37827	SKCM	ICGC	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.25
p.G186E	TCGA-FW-A3R5	SKCM	TCGA	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.25
p.H193Y	DO48435	BLCA	ICGC	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.7229
p.H193Y	DO37782	SKCM	ICGC	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.7229
p.T191A	DO3686	BRCA	ICGC	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.7139
p.S186P	DO223065	ESCA	ICGC	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.25
p.D201N	DO49067	HNSC	ICGC	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.1111
p.M189V	SIDM00234	Other Solid Cancers	GDSC	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.7208
p.M189V	TC-YIK	cervix	COSMIC	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.7208
p.G198V	SIDM00832	Colorectal Carcinoma	GDSC	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.1944
p.G198V	SW948	large intestine	COSMIC	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.1944
p.S180Y	SIDM00683	Prostate Carcinoma	GDSC	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.0833
p.S180Y	LNCaP-Clone-FGC	prostate	COSMIC	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.0833
p.H190Y	ACH-000641	Leukemia	CCLE	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.6118
p.H190Y	ACH-001036	Leukemia	CCLE	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.6118
p.H190Y	CMK	haematopoietic and lymphoid tissue	COSMIC	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.6118
p.K199E	NUGC-4	stomach	COSMIC	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.1667
p.D201V	MC-CAR	haematopoietic and lymphoid tissue	COSMIC	VHTSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.1111

Kaplan plot for HEPACAM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HEPACAM2

UniProt ID: A8MVW5

Entrez ID: 253012

Protein name: HEPACAM family member 2 (Mitotic kinetics regulator)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HEPACAM2 in