DegronMD

Uniprot ID: A8MVW5

Source protein: HEPACAM family member 2

Source gene: HEPACAM2

Class: DEG_SPOP_SBC_1

Location: 189:193

E3 ligase: SPOP

DEGRON score: 0.8164

ASA_SCORE: 65.18

COIL: 0.8464

CONS_SCORE: 0.4935

DSS_SCORE: 0.3878

HELIX: 0.0126

FCONS_SCORE: 0.7478

RIG_SCORE: 0.7319

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T203A	TCGA-BH-A18G	BRCA	TCGA	VHTSS	DEG_SPOP_SBC_1	0.5
p.S196F	TCGA-D3-A1Q5	SKCM	TCGA	VHTSS	DEG_SPOP_SBC_1	0.25
p.S196F	TCGA-EE-A2GC	SKCM	TCGA	VHTSS	DEG_SPOP_SBC_1	0.25
p.S196F	DO37839	SKCM	ICGC	VHTSS	DEG_SPOP_SBC_1	0.25
p.S196F	DO37827	SKCM	ICGC	VHTSS	DEG_SPOP_SBC_1	0.25
p.G186E	TCGA-FW-A3R5	SKCM	TCGA	VHTSS	DEG_SPOP_SBC_1	0.25
p.H193Y	DO48435	BLCA	ICGC	VHTSS	DEG_SPOP_SBC_1	0.7229
p.H193Y	DO37782	SKCM	ICGC	VHTSS	DEG_SPOP_SBC_1	0.7229
p.T191A	DO3686	BRCA	ICGC	VHTSS	DEG_SPOP_SBC_1	0.7139
p.S186P	DO223065	ESCA	ICGC	VHTSS	DEG_SPOP_SBC_1	0.25
p.D201N	DO49067	HNSC	ICGC	VHTSS	DEG_SPOP_SBC_1	0.1111
p.M189V	SIDM00234	Other Solid Cancers	GDSC	VHTSS	DEG_SPOP_SBC_1	0.7208
p.M189V	TC-YIK	cervix	COSMIC	VHTSS	DEG_SPOP_SBC_1	0.7208
p.G198V	SIDM00832	Colorectal Carcinoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.1944
p.G198V	SW948	large_intestine	COSMIC	VHTSS	DEG_SPOP_SBC_1	0.1944
p.S180Y	SIDM00683	Prostate Carcinoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.0833
p.S180Y	LNCaP-Clone-FGC	prostate	COSMIC	VHTSS	DEG_SPOP_SBC_1	0.0833
p.H190Y	ACH-000641	Leukemia	CCLE	VHTSS	DEG_SPOP_SBC_1	0.6118
p.H190Y	ACH-001036	Leukemia	CCLE	VHTSS	DEG_SPOP_SBC_1	0.6118
p.H190Y	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	VHTSS	DEG_SPOP_SBC_1	0.6118
p.K199E	NUGC-4	stomach	COSMIC	VHTSS	DEG_SPOP_SBC_1	0.1667
p.D201V	MC-CAR	haematopoietic_and_lymphoid_tissue	COSMIC	VHTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MVW5	HEPACAM family member 2	DEG_SPOP_SBC_1	189:193	VHTSS	SPOP	0.8164	More...
Q5H9F3	BCL-6 corepressor-like protein 1	DEG_SPOP_SBC_1	650:654	VHTSS	SPOP	0.9938	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1851:1855	VHTSS	SPOP	0.5519	More...
A8MX19	Putative protein FAM90A12P	DEG_SPOP_SBC_1	152:156	VHTSS	SPOP	0.9805	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons