DegronMD - Q5H9F3(BCORL1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S663C	TCGA-05-4244	LUAD	TCGA	VHTSS	DEG_SPOP_SBC_1	650:654	Mutation blocking phosphorylation signal	0.5278
p.S663C	DO23553	LUAD	ICGC	VHTSS	DEG_SPOP_SBC_1	650:654	Mutation blocking phosphorylation signal	0.5278
p.P873S	TCGA-06-5416	GBM	TCGA	SEFSGVPSL	DEG_COP1_1	867:875	Mutation altering degron motif	0.6752
p.P873S	DO10880	GBM	ICGC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation altering degron motif	0.6752
p.P862L	TCGA-17-Z022	LUAD	TCGA	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.1944
p.S682C	TCGA-21-1070	LUSC	TCGA	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation rewiring degron network	0.1944
p.S682C	DO27088	LUSC	ICGC	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation rewiring degron network	0.1944
p.E692K	TCGA-25-2393	OV	TCGA	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation altering degron motif	0.7022
p.E692K	DO32153	OV	ICGC	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation altering degron motif	0.7022
p.P699Q	TCGA-37-3789	LUSC	TCGA	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation rewiring degron network	0.1389
p.P699Q	TCGA-OR-A5KB	ACC	TCGA	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation rewiring degron network	0.1389
p.P699Q	DO26743	LUSC	ICGC	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation rewiring degron network	0.1389
p.V688A	TCGA-3S-AAYX	THYM	TCGA	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation altering degron motif	0.5825
p.P885T	TCGA-46-3765	LUSC	TCGA	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.0556
p.P885T	DO26959	LUSC	ICGC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.0556
p.R639S	TCGA-50-5051	LUAD	TCGA	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation rewiring degron network	0.1667
p.R639S	DO24576	LUAD	ICGC	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation rewiring degron network	0.1667
p.P645L	TCGA-A5-A0G1	UCEC	TCGA	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation altering degron motif	0.6471
p.P645L	TCGA-A5-A1OF	UCEC	TCGA	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation altering degron motif	0.6471
p.P645L	DO42568	UCEC	ICGC	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation altering degron motif	0.6471
p.P645L	DO42472	UCEC	ICGC	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation altering degron motif	0.6471
p.P699L	TCGA-A5-A0G1	UCEC	TCGA	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation rewiring degron network	0.1389
p.P699L	DO42472	UCEC	ICGC	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation rewiring degron network	0.1389
p.R1466W	TCGA-A5-A0VP	UCEC	TCGA	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation rewiring degron network	0.3056
p.H1451Q	TCGA-A5-A1OF	UCEC	TCGA	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation rewiring degron network	0.1111
p.D698Y	TCGA-A8-A085	BRCA	TCGA	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation rewiring degron network	0.1667
p.D698Y	DO1251	BRCA	ICGC	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation rewiring degron network	0.1667
p.P885H	TCGA-AP-A0LM	UCEC	TCGA	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.0556
p.P885H	TCGA-EB-A299	SKCM	TCGA	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.0556
p.P885H	DO37794	SKCM	ICGC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.0556
p.P885H	DO43306	UCEC	ICGC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.0556
p.R1452C	TCGA-AX-A1CE	UCEC	TCGA	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation rewiring degron network	0.1389
p.T1469N	TCGA-AX-A3FX	UCEC	TCGA	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation rewiring degron network	0.2222
p.T1469N	ACH-001794	Liposarcoma	CCLE	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation rewiring degron network	0.2222
p.T359P	TCGA-B0-5701	KIRC	TCGA	PMPTPTPS	DEG_SCF_FBW7_1	356:363	Mutation altering degron motif	0.7031
p.T359P	DO16240	KIRC	ICGC	PMPTPTPS	DEG_SCF_FBW7_1	356:363	Mutation altering degron motif	0.7031
p.P380L	TCGA-B5-A0K1	UCEC	TCGA	PIFTPAPT	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.1111
p.P380L	DO41839	UCEC	ICGC	PIFTPAPT	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.1111
p.P353S	TCGA-BH-A0AW	BRCA	TCGA	PMPTPTPS	DEG_SCF_FBW7_1	356:363	Mutation rewiring degron network	0.25
p.P353S	DO5005	BRCA	ICGC	PMPTPTPS	DEG_SCF_FBW7_1	356:363	Mutation rewiring degron network	0.25
p.W1468L	TCGA-BH-A18G	BRCA	TCGA	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation rewiring degron network	0.25
p.T369A	TCGA-BW-A5NP	LIHC	TCGA	PMPTPTPS	DEG_SCF_FBW7_1	356:363	Mutation rewiring degron network	0.1667
p.T369A	DO52172	LIHC	ICGC	PMPTPTPS	DEG_SCF_FBW7_1	356:363	Mutation rewiring degron network	0.1667
p.S1465F	TCGA-D6-A6EQ	HNSC	TCGA	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation altering degron motif	0.7982
p.G883R	TCGA-EE-A3AA	SKCM	TCGA	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.1111
p.G883R	TCGA-L3-A524	LUSC	TCGA	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.1111
p.G883R	DO45476	LUSC	ICGC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.1111
p.G883R	DO37571	SKCM	ICGC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.1111
p.G883E	TCGA-EE-A3AA	SKCM	TCGA	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.1111
p.G883E	DO37571	SKCM	ICGC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.1111
p.R1452S	TCGA-EE-A3AA	SKCM	TCGA	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation rewiring degron network	0.1389
p.A1459T	TCGA-EO-A22T	UCEC	TCGA	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation altering degron motif	0.7139
p.P356S	TCGA-EO-A22U	UCEC	TCGA	PMPTPTPS	DEG_SCF_FBW7_1	356:363	Mutation altering degron motif	0.6752
p.P356S	DO43755	UCEC	ICGC	PMPTPTPS	DEG_SCF_FBW7_1	356:363	Mutation altering degron motif	0.6752
p.P356S	ACH-000670	Lung Cancer	CCLE	PMPTPTPS	DEG_SCF_FBW7_1	356:363	Mutation altering degron motif	0.6752
p.S867L	TCGA-EO-A22X	UCEC	TCGA	SEFSGVPSL	DEG_COP1_1	867:875	Mutation altering degron motif	0.7667
p.S867L	DO43907	UCEC	ICGC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation altering degron motif	0.7667
p.P649H	TCGA-ER-A19T	SKCM	TCGA	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation altering degron motif	0.7694
p.P649H	DO51251	SKCM	ICGC	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation altering degron motif	0.7694
p.T1469I	TCGA-EY-A215	UCEC	TCGA	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation rewiring degron network	0.2222
p.D1470N	TCGA-FI-A2D5	UCEC	TCGA	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation rewiring degron network	0.1944
p.P691L	TCGA-FS-A4F5	SKCM	TCGA	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation altering degron motif	0.6471
p.P691L	DO37881	SKCM	ICGC	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation altering degron motif	0.6471
p.S659Y	TCGA-FU-A40J	CESC	TCGA	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation blocking phosphorylation signal	0.5833
p.S659Y	TCGA-FU-A40J	CESC	TCGA	VHTSS	DEG_SPOP_SBC_1	650:654	Mutation blocking phosphorylation signal	0.6389
p.S659Y	DO44314	CESC	ICGC	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation blocking phosphorylation signal	0.5833
p.S659Y	DO44314	CESC	ICGC	VHTSS	DEG_SPOP_SBC_1	650:654	Mutation blocking phosphorylation signal	0.6389
p.H651D	TCGA-NH-A5IV	COAD	TCGA	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation altering degron motif	0.6577
p.H651D	TCGA-NH-A5IV	COAD	TCGA	VHTSS	DEG_SPOP_SBC_1	650:654	Mutation altering degron motif	0.6577
p.H651D	DO49095	COAD	ICGC	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation altering degron motif	0.6577
p.H651D	DO49095	COAD	ICGC	VHTSS	DEG_SPOP_SBC_1	650:654	Mutation altering degron motif	0.6577
p.V881M	TCGA-VQ-A91E	STAD	TCGA	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.1667
p.V881M	DO51784	STAD	ICGC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.1667
p.E868K	DO1076	BRCA	ICGC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation altering degron motif	0.7022
p.P382H	DO222946	BTCA	ICGC	PIFTPAPT	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.1667
p.P645H	DO227549	COCA	ICGC	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation altering degron motif	0.7694
p.P645H	SIDM00333	Endometrial Carcinoma	GDSC	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation altering degron motif	0.7694
p.P645H	ACH-000988	Endometrial/Uterine Cancer	CCLE	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation altering degron motif	0.7694
p.P645H	MFE-319	endometrium	COSMIC	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation altering degron motif	0.7694
p.S878G	DO228941	LICA	ICGC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00305	Ovarian Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00608	Plasma Cell Myeloma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00425	Ovarian Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM01199	Hepatocellular Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00607	Glioblastoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00573	Glioblastoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00002	Neuroblastoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00394	Cervical Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00350	Head and Neck Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00364	B-Lymphoblastic Leukemia	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00251	Gastric Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00024	Non-Cancerous	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00502	B-Lymphoblastic Leukemia	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00357	Small Cell Lung Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM00045	Gastric Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM01735	Biliary Tract Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM01460	Glioma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM01393	Gastric Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM01320	Pancreatic Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.S878G	SIDM01378	Ovarian Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.25
p.M397I	DO228948	LICA	ICGC	PIFTPAPT	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.2778
p.V694L	DO229015	LICA	ICGC	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation rewiring degron network	0.2778
p.C679F	DO229029	LICA	ICGC	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation rewiring degron network	0.1111
p.G681C	DO229037	LICA	ICGC	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation rewiring degron network	0.1667
p.P1460L	DO229046	LICA	ICGC	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation altering degron motif	0.7582
p.I689V	DO50966	LICA	ICGC	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation altering degron motif	0.5965
p.T1457R	DO25985	LUAD	ICGC	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation rewiring degron network	0.2778
p.Q1455H	DO26374	LUAD	ICGC	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation substituting flanking lysine	0.3333
p.G883K	DO222632	MELA	ICGC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.1111
p.D1465G	DO46591	OV	ICGC	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation altering degron motif	0.7198
p.R639C	DO33904	PACA	ICGC	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation rewiring degron network	0.1667
p.R861W	DO48941	PBCA	ICGC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation rewiring degron network	0.1667
p.P691S	DO218850	SKCA	ICGC	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation altering degron motif	0.5641
p.L1475R	DO38631	STAD	ICGC	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation rewiring degron network	0.0556
p.S1474L	DO43755	UCEC	ICGC	PCTPSKS	DEG_SCF_FBW7_1	1459:1465	Mutation rewiring degron network	0.0833
p.A348V	SIDM00373	Endometrial Carcinoma	GDSC	PMPTPTPS	DEG_SCF_FBW7_1	356:363	Mutation rewiring degron network	0.1111
p.A348V	ACH-000974	Endometrial/Uterine Cancer	CCLE	PMPTPTPS	DEG_SCF_FBW7_1	356:363	Mutation rewiring degron network	0.1111
p.A348V	ACH-002026	Endometrial/Uterine Cancer	CCLE	PMPTPTPS	DEG_SCF_FBW7_1	356:363	Mutation rewiring degron network	0.1111
p.V872G	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation altering degron motif	0.7532
p.V872G	CTB-1	haematopoietic and lymphoid tissue	COSMIC	SEFSGVPSL	DEG_COP1_1	867:875	Mutation altering degron motif	0.7532
p.R639H	SIDM00217	Colorectal Carcinoma	GDSC	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation rewiring degron network	0.1667
p.R639H	ACH-000999	Colon/Colorectal Cancer	CCLE	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation rewiring degron network	0.1667
p.R639H	SNU-1040	large intestine	COSMIC	PVLTPVHT	DEG_SCF_FBW7_1	645:652	Mutation rewiring degron network	0.1667
p.V694M	SIDM01617	Endometrial Carcinoma	GDSC	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation rewiring degron network	0.2778
p.V694M	ACH-000994	Endometrial/Uterine Cancer	CCLE	FVIFPE	LIG_APCC_ABBA_1	687:692	Mutation rewiring degron network	0.2778
p.S363F	ACH-000777	Esophageal Cancer	CCLE	PMPTPTPS	DEG_SCF_FBW7_1	356:363	Mutation altering degron motif	0.7982
p.P360S	ACH-000973	Bladder Cancer	CCLE	PMPTPTPS	DEG_SCF_FBW7_1	356:363	Mutation altering degron motif	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BCORL1

UniProt ID: Q5H9F3

Entrez ID: 63035

Protein name: BCL-6 corepressor-like protein 1 (BCoR-L1) (BCoR-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BCORL1 in