DegronMD

Uniprot ID: Q5H9F3

Source protein: BCL-6 corepressor-like protein 1

Source gene: BCORL1

Class: DEG_COP1_1

Location: 867:875

E3 ligase: COP1

DEGRON score: 0.9395

ASA_SCORE: 70.1778

COIL: 0.8659

CONS_SCORE: 0.5022

DSS_SCORE: 0.4754

HELIX: 0.0719

FCONS_SCORE: 1.061

RIG_SCORE: 0.6522

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P873S	TCGA-06-5416	GBM	TCGA	SEFSGVPSL	DEG_COP1_1	0.6752
p.P873S	DO10880	GBM	ICGC	SEFSGVPSL	DEG_COP1_1	0.6752
p.P862L	TCGA-17-Z022	LUAD	TCGA	SEFSGVPSL	DEG_COP1_1	0.1944
p.P885T	TCGA-46-3765	LUSC	TCGA	SEFSGVPSL	DEG_COP1_1	0.0556
p.P885T	DO26959	LUSC	ICGC	SEFSGVPSL	DEG_COP1_1	0.0556
p.P885H	TCGA-AP-A0LM	UCEC	TCGA	SEFSGVPSL	DEG_COP1_1	0.0556
p.P885H	TCGA-EB-A299	SKCM	TCGA	SEFSGVPSL	DEG_COP1_1	0.0556
p.P885H	DO37794	SKCM	ICGC	SEFSGVPSL	DEG_COP1_1	0.0556
p.P885H	DO43306	UCEC	ICGC	SEFSGVPSL	DEG_COP1_1	0.0556
p.G883R	TCGA-EE-A3AA	SKCM	TCGA	SEFSGVPSL	DEG_COP1_1	0.1111
p.G883R	TCGA-L3-A524	LUSC	TCGA	SEFSGVPSL	DEG_COP1_1	0.1111
p.G883R	DO45476	LUSC	ICGC	SEFSGVPSL	DEG_COP1_1	0.1111
p.G883R	DO37571	SKCM	ICGC	SEFSGVPSL	DEG_COP1_1	0.1111
p.G883E	TCGA-EE-A3AA	SKCM	TCGA	SEFSGVPSL	DEG_COP1_1	0.1111
p.G883E	DO37571	SKCM	ICGC	SEFSGVPSL	DEG_COP1_1	0.1111
p.S867L	TCGA-EO-A22X	UCEC	TCGA	SEFSGVPSL	DEG_COP1_1	0.7667
p.S867L	DO43907	UCEC	ICGC	SEFSGVPSL	DEG_COP1_1	0.7667
p.V881M	TCGA-VQ-A91E	STAD	TCGA	SEFSGVPSL	DEG_COP1_1	0.1667
p.V881M	DO51784	STAD	ICGC	SEFSGVPSL	DEG_COP1_1	0.1667
p.E868K	DO1076	BRCA	ICGC	SEFSGVPSL	DEG_COP1_1	0.7022
p.S878G	DO228941	LICA	ICGC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00305	Ovarian Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00608	Plasma Cell Myeloma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00425	Ovarian Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM01199	Hepatocellular Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00607	Glioblastoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00573	Glioblastoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00002	Neuroblastoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00394	Cervical Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00350	Head and Neck Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00364	B-Lymphoblastic Leukemia	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00251	Gastric Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00024	Non-Cancerous	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00502	B-Lymphoblastic Leukemia	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00357	Small Cell Lung Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM00045	Gastric Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM01735	Biliary Tract Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM01460	Glioma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM01393	Gastric Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM01320	Pancreatic Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.S878G	SIDM01378	Ovarian Carcinoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.25
p.G883K	DO222632	MELA	ICGC	SEFSGVPSL	DEG_COP1_1	0.1111
p.R861W	DO48941	PBCA	ICGC	SEFSGVPSL	DEG_COP1_1	0.1667
p.V872G	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	SEFSGVPSL	DEG_COP1_1	0.7532
p.V872G	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	SEFSGVPSL	DEG_COP1_1	0.7532

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SEFSGVPSL

Degron related mutations and impact score

Drug responses associated with BCORL1 mutations

All proteins holding degron of SEFSGVPSL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5H9F3	BCL-6 corepressor-like protein 1	DEG_COP1_1	867:875	SEFSGVPSL	COP1	0.9395	More...