DegronMD

Uniprot ID: Q5H9F3

Source protein: BCL-6 corepressor-like protein 1

Source gene: BCORL1

Class: DEG_SCF_FBW7_1

Location: 645:652

E3 ligase: FBXW7

DEGRON score: 0.9905

ASA_SCORE: 88.25

COIL: 0.9203

CONS_SCORE: 0.6606

DSS_SCORE: 0.6181

HELIX: 0.0283

FCONS_SCORE: 1.0563

RIG_SCORE: 0.7066

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R639S	TCGA-50-5051	LUAD	TCGA	PVLTPVHT	DEG_SCF_FBW7_1	0.1667
p.R639S	DO24576	LUAD	ICGC	PVLTPVHT	DEG_SCF_FBW7_1	0.1667
p.P645L	TCGA-A5-A0G1	UCEC	TCGA	PVLTPVHT	DEG_SCF_FBW7_1	0.6471
p.P645L	TCGA-A5-A1OF	UCEC	TCGA	PVLTPVHT	DEG_SCF_FBW7_1	0.6471
p.P645L	DO42568	UCEC	ICGC	PVLTPVHT	DEG_SCF_FBW7_1	0.6471
p.P645L	DO42472	UCEC	ICGC	PVLTPVHT	DEG_SCF_FBW7_1	0.6471
p.P649H	TCGA-ER-A19T	SKCM	TCGA	PVLTPVHT	DEG_SCF_FBW7_1	0.7694
p.P649H	DO51251	SKCM	ICGC	PVLTPVHT	DEG_SCF_FBW7_1	0.7694
p.S659Y	TCGA-FU-A40J	CESC	TCGA	PVLTPVHT	DEG_SCF_FBW7_1	0.5833
p.S659Y	DO44314	CESC	ICGC	PVLTPVHT	DEG_SCF_FBW7_1	0.5833
p.H651D	TCGA-NH-A5IV	COAD	TCGA	PVLTPVHT	DEG_SCF_FBW7_1	0.6577
p.H651D	DO49095	COAD	ICGC	PVLTPVHT	DEG_SCF_FBW7_1	0.6577
p.P645H	DO227549	COCA	ICGC	PVLTPVHT	DEG_SCF_FBW7_1	0.7694
p.P645H	SIDM00333	Endometrial Carcinoma	GDSC	PVLTPVHT	DEG_SCF_FBW7_1	0.7694
p.P645H	ACH-000988	Endometrial/Uterine Cancer	CCLE	PVLTPVHT	DEG_SCF_FBW7_1	0.7694
p.P645H	MFE-319	endometrium	COSMIC	PVLTPVHT	DEG_SCF_FBW7_1	0.7694
p.R639C	DO33904	PACA	ICGC	PVLTPVHT	DEG_SCF_FBW7_1	0.1667
p.R639H	SIDM00217	Colorectal Carcinoma	GDSC	PVLTPVHT	DEG_SCF_FBW7_1	0.1667
p.R639H	ACH-000999	Colon/Colorectal Cancer	CCLE	PVLTPVHT	DEG_SCF_FBW7_1	0.1667
p.R639H	SNU-1040	large_intestine	COSMIC	PVLTPVHT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5H9F3	BCL-6 corepressor-like protein 1	DEG_SCF_FBW7_1	645:652	PVLTPVHT	FBXW7	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons