DegronMD

Uniprot ID: Q5H9F3

Source protein: BCL-6 corepressor-like protein 1

Source gene: BCORL1

Class: LIG_APCC_ABBA_1

Location: 687:692

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5021

ASA_SCORE: 77.3

COIL: 0.7687

CONS_SCORE: 0.6293

DSS_SCORE: 0.3194

HELIX: 0.1098

FCONS_SCORE: 1.0929

RIG_SCORE: 0.8762

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S682C	TCGA-21-1070	LUSC	TCGA	FVIFPE	LIG_APCC_ABBA_1	0.1944
p.S682C	DO27088	LUSC	ICGC	FVIFPE	LIG_APCC_ABBA_1	0.1944
p.E692K	TCGA-25-2393	OV	TCGA	FVIFPE	LIG_APCC_ABBA_1	0.7022
p.E692K	DO32153	OV	ICGC	FVIFPE	LIG_APCC_ABBA_1	0.7022
p.P699Q	TCGA-37-3789	LUSC	TCGA	FVIFPE	LIG_APCC_ABBA_1	0.1389
p.P699Q	TCGA-OR-A5KB	ACC	TCGA	FVIFPE	LIG_APCC_ABBA_1	0.1389
p.P699Q	DO26743	LUSC	ICGC	FVIFPE	LIG_APCC_ABBA_1	0.1389
p.V688A	TCGA-3S-AAYX	THYM	TCGA	FVIFPE	LIG_APCC_ABBA_1	0.5825
p.P699L	TCGA-A5-A0G1	UCEC	TCGA	FVIFPE	LIG_APCC_ABBA_1	0.1389
p.P699L	DO42472	UCEC	ICGC	FVIFPE	LIG_APCC_ABBA_1	0.1389
p.D698Y	TCGA-A8-A085	BRCA	TCGA	FVIFPE	LIG_APCC_ABBA_1	0.1667
p.D698Y	DO1251	BRCA	ICGC	FVIFPE	LIG_APCC_ABBA_1	0.1667
p.P691L	TCGA-FS-A4F5	SKCM	TCGA	FVIFPE	LIG_APCC_ABBA_1	0.6471
p.P691L	DO37881	SKCM	ICGC	FVIFPE	LIG_APCC_ABBA_1	0.6471
p.V694L	DO229015	LICA	ICGC	FVIFPE	LIG_APCC_ABBA_1	0.2778
p.C679F	DO229029	LICA	ICGC	FVIFPE	LIG_APCC_ABBA_1	0.1111
p.G681C	DO229037	LICA	ICGC	FVIFPE	LIG_APCC_ABBA_1	0.1667
p.I689V	DO50966	LICA	ICGC	FVIFPE	LIG_APCC_ABBA_1	0.5965
p.P691S	DO218850	SKCA	ICGC	FVIFPE	LIG_APCC_ABBA_1	0.5641
p.V694M	SIDM01617	Endometrial Carcinoma	GDSC	FVIFPE	LIG_APCC_ABBA_1	0.2778
p.V694M	ACH-000994	Endometrial/Uterine Cancer	CCLE	FVIFPE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5H9F3	BCL-6 corepressor-like protein 1	LIG_APCC_ABBA_1	687:692	FVIFPE	APC,CDC20,FZR1	0.5021	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons